SUN-075 Higher Fibrinogen and Clot Density in Patients with Acromegaly: The Role of Adverse Body Composition to the Increased Thrombotic Potential

Introduction: Patients with acromegaly have increased mortality rates compared with the general population, particularly due to cardiovascular and cerebrovascular disease. We hypothesized that one mechanism through which GH/IGF-1 excess increases vascular disease is via effects on hemostasis/fibrinolysis and subsequent clot formation. Patients and Methods: We conducted a case-control study in 40 patients with acromegaly and 40 age and sex-matched healthy controls. We measured parameters of metabolic profile, fibrinogen using the Clauss method and performed clot structure analysis using a validated turbidimetric assay. Results: Forty patients with acromegaly (21 males, mean age 53±13 years) were recruited. 30% had active disease (GH>1mcg/L and IGF-1 above the reference range), 27.5% had dichotomous GH/IGF-1 results and 42.5% were in remission. Compared with controls, patients had a less favorable metabolic profile with higher BMI (30±5.5 vs. 26.7±4.1 kg/m 2 , p=0.003), waist/hip ratio (0.91±0.08 vs. 0.87±0.08, p=0.045), total fat mass (29.8±10 vs. 23.4±10 kg, p=0.003) and triglycerides (1.5±0.9 vs. 1.1±0.5 mmol/L, p=0.02). Significantly higher fibrinogen levels were found in the patient group (3.59±1.56 vs. 2.58±0.37 mg/ml, p