Tumor Mutational Burden and Response Rate to PD-1 Inhibition
In a survey of the spectrum of mutational burdens in 27 types of cancers, there was a correlation between an increased mutational burden and the response to checkpoint inhibition of PD-1 and PD-L1.
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| Veröffentlicht in: | The New England journal of medicine 2017-12, Vol.377 (25), p.2500-2501 |
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| container_end_page | 2501 |
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| container_issue | 25 |
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| container_title | The New England journal of medicine |
| container_volume | 377 |
| creator | Yarchoan, Mark Hopkins, Alexander Jaffee, Elizabeth M |
| description | In a survey of the spectrum of mutational burdens in 27 types of cancers, there was a correlation between an increased mutational burden and the response to checkpoint inhibition of PD-1 and PD-L1. |
| doi_str_mv | 10.1056/NEJMc1713444 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | The New England journal of medicine, 2017-12, Vol.377 (25), p.2500-2501 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Antineoplastic Agents - therapeutic use B7-H1 Antigen - antagonists & inhibitors Biomarkers, Tumor DNA Mutational Analysis Humans Models, Genetic Mutation Neoplasms - drug therapy Neoplasms - genetics Programmed Cell Death 1 Receptor - antagonists & inhibitors |
| title | Tumor Mutational Burden and Response Rate to PD-1 Inhibition |
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