Tumor Mutational Burden and Response Rate to PD-1 Inhibition

In a survey of the spectrum of mutational burdens in 27 types of cancers, there was a correlation between an increased mutational burden and the response to checkpoint inhibition of PD-1 and PD-L1.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2017-12, Vol.377 (25), p.2500-2501
Hauptverfasser:	Yarchoan, Mark, Hopkins, Alexander, Jaffee, Elizabeth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use B7-H1 Antigen - antagonists & inhibitors Biomarkers, Tumor DNA Mutational Analysis Humans Models, Genetic Mutation Neoplasms - drug therapy Neoplasms - genetics Programmed Cell Death 1 Receptor - antagonists & inhibitors
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Beschreibung
Zusammenfassung:	In a survey of the spectrum of mutational burdens in 27 types of cancers, there was a correlation between an increased mutational burden and the response to checkpoint inhibition of PD-1 and PD-L1.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMc1713444