Extracellular Processing of Lysyl Oxidase-like 2 and Its Effect on Amine Oxidase Activity

Overexpression of lysyl oxidase-like 2 (LOXL2) is associated with several hepatic and vascular fibrotic diseases and tumor progression in some aggressive cancers. Secreted LOXL2 promotes extracellular matrix cross-linking by catalyzing the oxidative deamination of peptidyl lysine. A great deal remai...

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Veröffentlicht in:	Biochemistry (Easton) 2018-12, Vol.57 (51), p.6973-6983
Hauptverfasser:	Okada, Kazushi, Moon, Hee-Jung, Finney, Joel, Meier, Alex, Mure, Minae
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Oxidoreductases - chemistry Amino Acid Oxidoreductases - genetics Amino Acid Oxidoreductases - metabolism Amino Acid Sequence Amino Acid Substitution Binding Sites Breast Neoplasms - enzymology Cell Line Collagen Type IV - metabolism Female Gene Knockdown Techniques HEK293 Cells Humans Mutagenesis, Site-Directed Proprotein Convertases - antagonists & inhibitors Proprotein Convertases - genetics Proprotein Convertases - metabolism Protein Domains Protein Processing, Post-Translational Protein-Lysine 6-Oxidase - chemistry Protein-Lysine 6-Oxidase - genetics Protein-Lysine 6-Oxidase - metabolism RNA, Small Interfering - genetics Serine Endopeptidases - genetics Serine Endopeptidases - metabolism
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