Indocyanine-green-assisted near-infrared dental imaging - the feasibility of in vivo imaging and the optimization of imaging conditions
X-ray-based imaging, including computed tomography, plays a crucial role in the diagnosis and surgery of impacted teeth that affects over 25% of the human population. But the greatest disadvantage of this technique is ionizing radiation risk to the patients. Here we describe a completely ionizing-ra...
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Veröffentlicht in: | Scientific reports 2019-06, Vol.9 (1), p.8238-8238, Article 8238 |
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Sprache: | eng |
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Zusammenfassung: | X-ray-based imaging, including computed tomography, plays a crucial role in the diagnosis and surgery of impacted teeth that affects over 25% of the human population. But the greatest disadvantage of this technique is ionizing radiation risk to the patients. Here we describe a completely ionizing-radiation-free
in vivo
near-infrared (NIR) fluoresence dental imaging with indocyanine green (ICG) agent that has rarely been applied in dental imaging. Our method can acquire dental structure images within a short period (only 10 minutes after injection) without ionizing radiation risk. NIR enables the observation of dental structures that are not distinguishable under visible conditions. At prolonged 72 hours, only molar regions remained highlighted; the contrast between molar regions and surrounding tissues was prominent; this is particularly useful for
in vivo
dental imaging. Using the quantitative spectral analysis, we found the peak wavelengths of ICG fluorescence shifted along with the injection time: the peak wavelength shifted 8 nm (from 819 nm to 811 nm) in 0~72 hours. The injection methods of tail vein
v.s
. intradermal injections caused ~3 nm shift. ICG-assisted NIR fluorescence imaging can serve as a useful tool for
in vivo
real-time diagnosis in dental clinics and surgeries without ionizing radiation risk. |
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ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-019-44660-y |