Intestinal microbiome disruption in patients in a long-term acute care hospital: A case for development of microbiome disruption indices to improve infection prevention

Highlights • Antibiotic exposure was inversely correlated with intestinal microbiome diversity. • Diversity was lower in patients who received third- or fourth-generation cephalosporins. • Charlson Comorbidity Index score was inversely correlated with microbiome diversity. • Directly measuring micro...

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Veröffentlicht in:American journal of infection control 2016-07, Vol.44 (7), p.830-836
Hauptverfasser: Halpin, Alison Laufer, PhD, de Man, Tom J.B., MS, Kraft, Colleen S., MD, Perry, K. Allison, MS, Chan, Austin W., MD, Lieu, Sung, MD, Mikell, Jeffrey, MD, Limbago, Brandi M., PhD, McDonald, L. Clifford, MD
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Sprache:eng
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Zusammenfassung:Highlights • Antibiotic exposure was inversely correlated with intestinal microbiome diversity. • Diversity was lower in patients who received third- or fourth-generation cephalosporins. • Charlson Comorbidity Index score was inversely correlated with microbiome diversity. • Directly measuring microbiome disruption might be most predictive of adverse events. • Microbiome disruption indices have the potential to improve infection control efforts.
ISSN:0196-6553
1527-3296
DOI:10.1016/j.ajic.2016.01.003