Intestinal microbiome disruption in patients in a long-term acute care hospital: A case for development of microbiome disruption indices to improve infection prevention
Highlights • Antibiotic exposure was inversely correlated with intestinal microbiome diversity. • Diversity was lower in patients who received third- or fourth-generation cephalosporins. • Charlson Comorbidity Index score was inversely correlated with microbiome diversity. • Directly measuring micro...
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Veröffentlicht in: | American journal of infection control 2016-07, Vol.44 (7), p.830-836 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Highlights • Antibiotic exposure was inversely correlated with intestinal microbiome diversity. • Diversity was lower in patients who received third- or fourth-generation cephalosporins. • Charlson Comorbidity Index score was inversely correlated with microbiome diversity. • Directly measuring microbiome disruption might be most predictive of adverse events. • Microbiome disruption indices have the potential to improve infection control efforts. |
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ISSN: | 0196-6553 1527-3296 |
DOI: | 10.1016/j.ajic.2016.01.003 |