The relationship between proton pump inhibitors and renal disease

Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the secretion of gastric acid. PPIs may trigger acute interstitial nephritis, a potentially severe adverse event commonly associated with acute kidney injury. Studies have found that pr...

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Veröffentlicht in:Brazilian Journal of Nephrology 2018-07, Vol.40 (3), p.301-306
Hauptverfasser: Morschel, Carine Franco, Mafra, Denise, Eduardo, José Carlos Carraro
Format: Artikel
Sprache:eng
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Zusammenfassung:Proton pump inhibitors (PPIs) bind to enzyme H+/K+-ATPase and inhibit its activity in the stomach, thus decreasing the secretion of gastric acid. PPIs may trigger acute interstitial nephritis, a potentially severe adverse event commonly associated with acute kidney injury. Studies have found that prolonged use of PPIs may increase the risk of chronic kidney disease (CKD). The increase in prescription and inadequate use of this class of medication calls for studies on the effects of prolonged PPI therapy on renal function. Therefore, this review aimed to analyze recent studies on the matter and discuss the possible consequences of the long-term use of PPIs on renal function.
ISSN:0101-2800
2175-8239
2175-8239
DOI:10.1590/2175-8239-JBN-2018-0021