Microbiome Profiles of Ligature-Induced Periodontitis in Nonhuman Primates across the Life Span

This investigation compared the microbiomes colonizing teeth during the initiation, progression, and resolution of periodontitis in nonhuman primates ( ) at different ages. Subgingival plaque samples were collected at baseline; 0.5, 1, and 3 months following ligature-induced periodontitis; and follo...

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Veröffentlicht in:	Infection and immunity 2019-06, Vol.87 (6)
Hauptverfasser:	Kirakodu, Sreenatha, Chen, Jin, Gonzalez Martinez, Janis, Gonzalez, Octavio A, Ebersole, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Bacteria - classification Bacteria - genetics Bacteria - isolation & purification Female Host-Associated Microbial Communities Macaca mulatta - growth & development Macaca mulatta - microbiology Male Microbiota Mouth - microbiology Periodontitis - microbiology Periodontitis - physiopathology Periodontitis - veterinary Phylogeny Primate Diseases - microbiology Primate Diseases - physiopathology
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Beschreibung
Zusammenfassung:	This investigation compared the microbiomes colonizing teeth during the initiation, progression, and resolution of periodontitis in nonhuman primates ( ) at different ages. Subgingival plaque samples were collected at baseline; 0.5, 1, and 3 months following ligature-induced periodontitis; and following naturally occurring disease resolution at 5 months. Samples were analyzed using 16S amplicon sequencing to identify bacterial profiles across age groups: young (
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.00067-19