Nanoparticles: Oral Delivery for Protein and Peptide Drugs

Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and muco...

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Veröffentlicht in:AAPS PharmSciTech 2019-05, Vol.20 (5), p.190
Hauptverfasser: Cao, Shu-jun, Xu, Shuo, Wang, Hui-ming, Ling, Yong, Dong, Jiahua, Xia, Rui-dong, Sun, Xiang-hong
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Sprache:eng
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Zusammenfassung:Protein and peptide drugs have many advantages, such as high bioactivity and specificity, strong solubility, and low toxicity. Therefore, the strategies for improving the bioavailability of protein peptides are reviewed, including chemical modification of nanocarriers, absorption enhancers, and mucous adhesion systems. The status, advantages, and disadvantages of various strategies are systematically analyzed. The systematic and personalized design of various factors affecting the release and absorption of drugs based on nanoparticles is pointed out. It is expected to design a protein peptide oral delivery system that can be applied in the clinic.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-019-1325-z