Oxidation of ethanol in the brain and its consequences
Acetaldehyde, a toxic byproduct of alcohol (i.e., ethanol) metabolism, has long been suspected of causing at least some of the central nervous system actions of ethanol. However, the data to support such a hypothesis have been difficult to obtain. One roadblock is the very low blood levels of acetal...
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| Veröffentlicht in: | Alcohol research & health 2006-01, Vol.29 (4), p.266-273 |
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| creator | Deitrich, Richard Zimatkin, Sergey Pronko, Sergey |
| description | Acetaldehyde, a toxic byproduct of alcohol (i.e., ethanol) metabolism, has long been suspected of causing at least some of the central nervous system actions of ethanol. However, the data to support such a hypothesis have been difficult to obtain. One roadblock is the very low blood levels of acetaldehyde following ethanol intake and the finding that even elevated acetaldehyde levels in the blood do not easily gain access to the brain. The recent discovery of the oxidation of ethanol to acetaldehyde in the adult brain may help explain the acute effects of ethanol. |
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However, the data to support such a hypothesis have been difficult to obtain. One roadblock is the very low blood levels of acetaldehyde following ethanol intake and the finding that even elevated acetaldehyde levels in the blood do not easily gain access to the brain. The recent discovery of the oxidation of ethanol to acetaldehyde in the adult brain may help explain the acute effects of ethanol.</description><identifier>ISSN: 1535-7414</identifier><identifier>ISSN: 2168-3492</identifier><identifier>EISSN: 1930-0573</identifier><identifier>EISSN: 2169-4796</identifier><identifier>PMID: 17718405</identifier><language>eng</language><publisher>United States: U.S. Government Printing Office</publisher><subject>Acetaldehyde ; Acetaldehyde - metabolism ; Alcohol ; Alcohol Dehydrogenase - metabolism ; Alcohol Drinking - metabolism ; Alcohol, Denatured ; Aldehydes ; Behavior ; Brain ; Brain - drug effects ; Catalase - metabolism ; Chemical properties ; Cytochrome P-450 CYP2E1 - metabolism ; Ethanol - metabolism ; Humans ; Nervous system ; Oxidation-Reduction ; Oxidation-reduction reaction ; Physiological aspects ; Studies</subject><ispartof>Alcohol research & health, 2006-01, Vol.29 (4), p.266-273</ispartof><rights>COPYRIGHT 2006 U.S. Government Printing Office</rights><rights>Copyright Superintendent of Documents 2006</rights><rights>2006</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527035/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527035/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17718405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deitrich, Richard</creatorcontrib><creatorcontrib>Zimatkin, Sergey</creatorcontrib><creatorcontrib>Pronko, Sergey</creatorcontrib><title>Oxidation of ethanol in the brain and its consequences</title><title>Alcohol research & health</title><addtitle>Alcohol Res Health</addtitle><description>Acetaldehyde, a toxic byproduct of alcohol (i.e., ethanol) metabolism, has long been suspected of causing at least some of the central nervous system actions of ethanol. 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The recent discovery of the oxidation of ethanol to acetaldehyde in the adult brain may help explain the acute effects of ethanol.</description><subject>Acetaldehyde</subject><subject>Acetaldehyde - metabolism</subject><subject>Alcohol</subject><subject>Alcohol Dehydrogenase - metabolism</subject><subject>Alcohol Drinking - metabolism</subject><subject>Alcohol, Denatured</subject><subject>Aldehydes</subject><subject>Behavior</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Catalase - metabolism</subject><subject>Chemical properties</subject><subject>Cytochrome P-450 CYP2E1 - metabolism</subject><subject>Ethanol - metabolism</subject><subject>Humans</subject><subject>Nervous system</subject><subject>Oxidation-Reduction</subject><subject>Oxidation-reduction reaction</subject><subject>Physiological aspects</subject><subject>Studies</subject><issn>1535-7414</issn><issn>2168-3492</issn><issn>1930-0573</issn><issn>2169-4796</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkUtLAzEQgBdRrK-_IIs3DytJJsluLkIpWoWCFz2H2Wx2G2mTuklF_70BH1goOcww883HDDkoTqgCUhFRw2HOBYiq5pRPitMYXwmhIIEeFxNa17ThRJwU8unDdZhc8GXoS5uW6MOqdL5MS1u2I-YMfVe6FEsTfLRvW-uNjefFUY-raC9-4lnxcn_3PHuoFk_zx9l0UQ0ALFXS1KKVYJjtWlBACXBEoApbSpVkiD02gMagZapjjBjBDQfZE8KNaoSCs-L227vZtmvbGevTiCu9Gd0ax08d0OndjndLPYR3LQWrCYgsuPoRjCHvHpN-DdvR5501Y4zXjCueoeobGnBltfN9yC4zWG-zMnjbu1yeUqkaJqUimb_Zw-fX2bUzeweudwYyk-xHGnAbo27mi1328v_Jf7f-_hl8AU49kbE</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Deitrich, Richard</creator><creator>Zimatkin, Sergey</creator><creator>Pronko, Sergey</creator><general>U.S. Government Printing Office</general><general>Superintendent of Documents</general><general>National Institute on Alcohol Abuse and Alcoholism</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8GL</scope><scope>0-V</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>88J</scope><scope>8AF</scope><scope>8AM</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K7.</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0O</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M2R</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>5PM</scope></search><sort><creationdate>20060101</creationdate><title>Oxidation of ethanol in the brain and its consequences</title><author>Deitrich, Richard ; Zimatkin, Sergey ; Pronko, Sergey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g332t-6c75b63c2edb3931034aa319ab11962aafa83accae29d220c54c436f004c98593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acetaldehyde</topic><topic>Acetaldehyde - 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| source | U.S. Government Documents; MEDLINE; PubMed Central; PubMed Central Open Access |
| subjects | Acetaldehyde Acetaldehyde - metabolism Alcohol Alcohol Dehydrogenase - metabolism Alcohol Drinking - metabolism Alcohol, Denatured Aldehydes Behavior Brain Brain - drug effects Catalase - metabolism Chemical properties Cytochrome P-450 CYP2E1 - metabolism Ethanol - metabolism Humans Nervous system Oxidation-Reduction Oxidation-reduction reaction Physiological aspects Studies |
| title | Oxidation of ethanol in the brain and its consequences |
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