Oxidation of ethanol in the brain and its consequences

Acetaldehyde, a toxic byproduct of alcohol (i.e., ethanol) metabolism, has long been suspected of causing at least some of the central nervous system actions of ethanol. However, the data to support such a hypothesis have been difficult to obtain. One roadblock is the very low blood levels of acetal...

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Veröffentlicht in:	Alcohol research & health 2006-01, Vol.29 (4), p.266-273
Hauptverfasser:	Deitrich, Richard, Zimatkin, Sergey, Pronko, Sergey
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde Acetaldehyde - metabolism Alcohol Alcohol Dehydrogenase - metabolism Alcohol Drinking - metabolism Alcohol, Denatured Aldehydes Behavior Brain Brain - drug effects Catalase - metabolism Chemical properties Cytochrome P-450 CYP2E1 - metabolism Ethanol - metabolism Humans Nervous system Oxidation-Reduction Oxidation-reduction reaction Physiological aspects Studies
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Zusammenfassung:	Acetaldehyde, a toxic byproduct of alcohol (i.e., ethanol) metabolism, has long been suspected of causing at least some of the central nervous system actions of ethanol. However, the data to support such a hypothesis have been difficult to obtain. One roadblock is the very low blood levels of acetaldehyde following ethanol intake and the finding that even elevated acetaldehyde levels in the blood do not easily gain access to the brain. The recent discovery of the oxidation of ethanol to acetaldehyde in the adult brain may help explain the acute effects of ethanol.
ISSN:	1535-7414 2168-3492 1930-0573 2169-4796