Molecular Basis of Redox Signaling

Results from the study indicate that GC-DNA provided in the cell culture medium interacts with the cell surface, induces NOX4 expression, and undergoes oxidation by augmentation of reactive oxygen production. [...]the incorporation and expression of cell-free DNA in cancer cells may harbor utility for therapeutic development. P. V. Avdonin et al. uncovered that H2O2 synergizes with calcium-mobilizing agonists of the 5-hydroxytryptamine receptors 5-HT1B and 5-HT2B through the induction of endogenous oxidative stress in human umbilical vein endothelial cells and suggested that H2O2 potentiation of agonist-induced calcium signaling in endothelial cells may contribute to vasorelaxation. E. Richard et al. summarize the current knowledge on the pathophysiological role of reactive oxygen species and redox imbalance in inborn errors of metabolism (IEM), with a focus on selected branched-chain amino acid disorders, organic acidurias, and homocystinuria.