Oral versus Intravenous Antibiotics for Bone and Joint Infection

Oral versus Intravenous Antibiotics for Bone and Joint Infection

Orthopedic infections are typically treated with intravenous antibiotics. In this trial, 1054 participants with complex orthopedic infections were assigned to receive either oral or intravenous antibiotics for the first 6 weeks of treatment. At 1 year, oral therapy was noninferior to intravenous the...

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Veröffentlicht in:The New England journal of medicine 2019-01, Vol.380 (5), p.425-436
Hauptverfasser: Li, Ho-Kwong, Rombach, Ines, Zambellas, Rhea, Walker, A. Sarah, McNally, Martin A, Atkins, Bridget L, Lipsky, Benjamin A, Hughes, Harriet C, Bose, Deepa, Kümin, Michelle, Scarborough, Claire, Matthews, Philippa C, Brent, Andrew J, Lomas, Jose, Gundle, Roger, Rogers, Mark, Taylor, Adrian, Angus, Brian, Byren, Ivor, Berendt, Anthony R, Warren, Simon, Fitzgerald, Fiona E, Mack, Damien J.F, Hopkins, Susan, Folb, Jonathan, Reynolds, Helen E, Moore, Elinor, Marshall, Jocelyn, Jenkins, Neil, Moran, Christopher E, Woodhouse, Andrew F, Stafford, Samantha, Seaton, R. Andrew, Vallance, Claire, Hemsley, Carolyn J, Bisnauthsing, Karen, Sandoe, Jonathan A.T, Aggarwal, Ila, Ellis, Simon C, Bunn, Deborah J, Sutherland, Rebecca K, Barlow, Gavin, Cooper, Cushla, Geue, Claudia, McMeekin, Nicola, Briggs, Andrew H, Sendi, Parham, Khatamzas, Elham, Wangrangsimakul, Tri, Wong, T.H. Nicholas, Barrett, Lucinda K, Alvand, Abtin, Old, C. Fraser, Bostock, Jennifer, Paul, John, Cooke, Graham, Thwaites, Guy E, Bejon, Philip, Scarborough, Matthew
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Intravenous
Administration, Oral
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - pharmacokinetics
Antibiotics
Biomedical research
Bone Diseases, Infectious - drug therapy
Committees
Female
Humans
Infections
Intention to Treat Analysis
Intravenous administration
Intravenous therapy
Joint diseases
Joint Diseases - drug therapy
Joint surgery
Male
Medical research
Medication Adherence
Middle Aged
Orthopedics
Prostheses
Sensitivity analysis
Surgery
Treatment Outcome
Young Adult
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Beschreibung
Zusammenfassung:Orthopedic infections are typically treated with intravenous antibiotics. In this trial, 1054 participants with complex orthopedic infections were assigned to receive either oral or intravenous antibiotics for the first 6 weeks of treatment. At 1 year, oral therapy was noninferior to intravenous therapy.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa1710926