Circulating microRNAs in plasma among men with low‐grade and high‐grade prostate cancer at prostate biopsy

Background MicroRNAs (miRNAs or miR‐) have been linked to factors associated with aggressive prostate cancer such as biochemical recurrence and metastasis. We investigated whether circulating miRNAs in plasma could be used as diagnostic biomarkers for more aggressive prostate cancer at prostate biop...

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Veröffentlicht in:	The Prostate 2019-06, Vol.79 (9), p.961-968
Hauptverfasser:	McDonald, Alicia C., Vira, Manish, Walter, Vonn, Shen, Jing, Raman, Jay D., Sanda, Martin G., Patil, Dattatraya, Taioli, Emanuela
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Aged, 80 and over aggressive prostate cancer biomarker Biomarkers Biopsy Circulating MicroRNA - biosynthesis Circulating MicroRNA - blood Circulating MicroRNA - genetics Cross-Sectional Studies Humans Male Metastases MicroRNAs Middle Aged miRNA Neoplasm Grading Prostate cancer Prostatic Neoplasms - blood Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Risk groups Statistical analysis
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Zusammenfassung:	Background MicroRNAs (miRNAs or miR‐) have been linked to factors associated with aggressive prostate cancer such as biochemical recurrence and metastasis. We investigated whether circulating miRNAs in plasma could be used as diagnostic biomarkers for more aggressive prostate cancer at prostate biopsy. Methods Men, aged 40 years and above, newly diagnosed with prostate cancer were categorized into two risk groups, low‐grade (Gleason score, 6 or 7 [3 + 4] and serum prostate‐specific antigen [PSA],
ISSN:	0270-4137 1097-0045
DOI:	10.1002/pros.23803