Comparing phenotypic variation between inbred and outbred mice

Inbred mice are preferred over outbred mice because it is assumed that they display less trait variability. We compared coefficients of variation and did not find evidence of greater trait stability in inbred mice. We conclude that contrary to conventional wisdom, outbred mice might be better subjec...

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Veröffentlicht in:	Nature methods 2018-12, Vol.15 (12), p.994-996
Hauptverfasser:	Tuttle, Alexander H., Philip, Vivek M., Chesler, Elissa J., Mogil, Jeffrey S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/334/1874/345 631/1647/767/1424 631/208/1515 Analysis Animal experimentation Animals Behavior Bioinformatics Biological Microscopy Biological Techniques Biological Variation, Population Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedical research Coefficient of variation Comment Datasets Displays (Marketing) Experiments Genetic Variation House mouse Hypotheses Inbreeding Life Sciences Males Medical research Mice Mice, Inbred Strains Mice, Mutant Strains Neurosciences Phenotypes Phenotypic variations Population Proteomics Software Universities and colleges
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Beschreibung
Zusammenfassung:	Inbred mice are preferred over outbred mice because it is assumed that they display less trait variability. We compared coefficients of variation and did not find evidence of greater trait stability in inbred mice. We conclude that contrary to conventional wisdom, outbred mice might be better subjects for most biomedical research.
ISSN:	1548-7091 1548-7105
DOI:	10.1038/s41592-018-0224-7