A262 QUALITY OF LIFE IN PRE-ADOLESCENT CHILDREN AFTER PEDIATRIC LIVER TRANSPLANT FOR BILIARY ATRESIA IS SIMILAR IN EUROPE AND CANADA

Abstract Background Biliary atresia (BA) is the commonest indication for pediatric LT performed in infants, with excellent long-term patient and graft survival world-wide. Optimizing durable outcomes for this patient population can be enhanced by understanding health-related quality of life (HRQoL) concerns. Aims This pilot study aimed to evaluate and compare HRQoL of middle-school aged BA subjects who underwent LT in Europe and Canada, and to explore the relationship between HRQoL with demographic and medical variables. Methods Following available guidelines, the English-version of a pediatric liver transplant-specific HRQoL questionnaire (PeLTQL) available for children 8 to 18 years, was translated and cross-culturally adapted into five different languages. Inclusion criteria included BA subjects with current age between 8 to 12 years who underwent LT before the age of two years followed in one of 8 different pediatric LT centers in Canada or in a ChilSFree/EPLTN network program. Patients completed validated disease-specific (PeLTQL) and generic (PedsQL™) HRQoL tools. Their parents completed the corresponding, validated parent-proxy tools. Total PeLTQL and PedsQLTM scores range between 0 and 100, with higher scores indicating better HRQoL. Patient demographics and medical variables were also reviewed. Results A total of 64 [female 54%, white 83.4%, median age 9.77 (range 8.05–12) years] BA subjects 6 or more years after LT were evaluated. Polish, Spanish, Italian, English, German and French questionnaires were completed by 19, 18, 10, 10, 5 and 2 BA subjects respectively. High correlation was seen between patient-reported and parent-reported PeLTQL scores (r=.71, p