Differential Mechanisms of Inflammation and Endothelial Dysfunction by HIV-1 Subtype-B and Recombinant CRF02_AG Tat Proteins on Human Brain Microvascular Endothelial Cells: Implications for Viral Neuropathogenesis

The recombinant HIV-1 CRF02_AG is prevalent in West-Central Africa but its effects on the blood-brain barrier (BBB) and HIV-associated neurocognitive disorders (HAND) are not known. We analyzed the effects of Tat from HIV-1 subtype-B (Tat.B) and CRF02_AG (Tat.AG) on primary human brain microvascular...

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Veröffentlicht in:	Molecular neurobiology 2018-02, Vol.55 (2), p.1352-1363
Hauptverfasser:	Bhargavan, Biju, Kanmogne, Georgette D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 Biomedical and Life Sciences Biomedicine Blood-brain barrier Blood-Brain Barrier - cytology Blood-Brain Barrier - metabolism Blood-Brain Barrier - virology Brain Brain - cytology Brain - metabolism Brain - virology c-Jun protein Cell Adhesion Cell Biology Cell Movement - physiology Central nervous system Cognition Endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Endothelial Cells - virology Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Endothelium, Vascular - virology HIV Infections - metabolism Humans Inflammation - metabolism Inflammation - virology Interleukin 1 Interleukin 6 Interleukin-6 - metabolism JNK protein Kinases MAP kinase Microvasculature Monocytes - cytology Monocytes - metabolism Monocytes - virology Neurobiology Neurology Neuropathogenesis Neurosciences NF-κB protein Protein kinase Proteins RelB protein Serine tat Gene Products, Human Immunodeficiency Virus - metabolism Tat protein Transcription factors Zonula occludens-1 protein
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Zusammenfassung:	The recombinant HIV-1 CRF02_AG is prevalent in West-Central Africa but its effects on the blood-brain barrier (BBB) and HIV-associated neurocognitive disorders (HAND) are not known. We analyzed the effects of Tat from HIV-1 subtype-B (Tat.B) and CRF02_AG (Tat.AG) on primary human brain microvascular endothelial cells (HBMEC), the major BBB component. Exposure of HBMEC to Tat.B increased IL-6 expression and transcription by 9- ( P
ISSN:	0893-7648 1559-1182
DOI:	10.1007/s12035-017-0382-0