Lactobacillus maintains healthy gut mucosa by producing L-Ornithine

Gut mucosal layers are crucial in maintaining the gut barrier function. Gut microbiota regulate homeostasis of gut mucosal layer via gut immune cells such as RORγt (+) IL-22(+) ILC3 cells, which can influence the proliferation of mucosal cells and the production of mucin. However, it is unclear how...

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Veröffentlicht in:	Communications biology 2019-05, Vol.2 (1), p.171-171, Article 171
Hauptverfasser:	Qi, Houbao, Li, Yuanyuan, Yun, Huan, Zhang, Tong, Huang, Yugang, Zhou, Jiang, Yan, Hui, Wei, Jianmei, Liu, Yingquan, Zhang, Zhiqian, Gao, Yunhuan, Che, Yongzhe, Su, Xiaomin, Zhu, Dashuai, Zhang, Yuan, Zhong, Jin, Yang, Rongcun
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/51 631/250/347 631/326/41/2533 64 64/60 82 82/51 96 96/106 96/31 96/95 Animals Arginine Basic Helix-Loop-Helix Transcription Factors - metabolism Biology Biomedical and Life Sciences Cell proliferation Epithelial cells Epithelial Cells - immunology Epithelial Cells - metabolism Epithelial Cells - microbiology Female Gastrointestinal Microbiome - immunology Gastrointestinal Microbiome - physiology Germ-Free Life Homeostasis Humans Interleukin 22 Intestinal microflora Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Lactobacillus - immunology Life Sciences Male Metabolism Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microbiota Mucin Mucosal immunity Mucus - metabolism Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Ornithine Ornithine - biosynthesis Pancreatitis-Associated Proteins - genetics Pancreatitis-Associated Proteins - metabolism Receptors, Aryl Hydrocarbon - metabolism Transgenic mice Tryptophan
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