IgG4-related disease in a patient with HIV infection

A 47-year-old HIV-positive man with good immune and virological status presented with chronic multiple enlarged lymph nodes, lung disease and eosinophilia. Radiologic tests showed enlarged cervical, thoracic and axillary lymph nodes, with interstitial lung damage. After several non-specific histolog...

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Veröffentlicht in:	BMJ case reports 2019-04, Vol.12 (4), p.e226809
Hauptverfasser:	Ron, Raquel, Ruz-Caracuel, Ignacio, García, Eugenia, Montes-Ramírez, María Luisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis Azathioprine - therapeutic use Biopsy Case reports Drug dosages Dyspnea - etiology Dyspnea - immunology Dyspnea - physiopathology Glucocorticoids - therapeutic use Hepatitis HIV HIV Infections - immunology HIV Infections - physiopathology Human immunodeficiency virus Humans Hypertension Immunoglobulin G - blood Immunoglobulin G4-Related Disease - diagnosis Immunoglobulin G4-Related Disease - physiopathology Immunohistochemistry Immunosuppressive Agents - therapeutic use Infections Liver diseases Lung Diseases, Interstitial - diagnosis Lung Diseases, Interstitial - immunology Lung Diseases, Interstitial - physiopathology Lymph Nodes - pathology Lymphatic system Male Middle Aged Patients Prednisone - therapeutic use Sarcoidosis Tomography, X-Ray Computed Treatment Outcome Unusual Association of Diseases/Symptoms
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Beschreibung
Zusammenfassung:	A 47-year-old HIV-positive man with good immune and virological status presented with chronic multiple enlarged lymph nodes, lung disease and eosinophilia. Radiologic tests showed enlarged cervical, thoracic and axillary lymph nodes, with interstitial lung damage. After several non-specific histologic studies, an elevated serum IgG4 level led us to request immunohistochemistry of a lymph node sample. The test confirmed the diagnosis of IgG4-related disease.
ISSN:	1757-790X 1757-790X
DOI:	10.1136/bcr-2018-226809