Patterns of olfactory bulb neurogenesis in the adult zebrafish are altered following reversible deafferentation

Highlights • Reversible deafferentation affects cell genesis in the olfactory bulbs of zebrafish. • Chronic deafferentation increases new cell migration into both olfactory bulbs. • Most new cells that enter the olfactory bulb during deafferentation do not survive. • Reafferentation sustains increas...

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Veröffentlicht in:	Neuroscience 2016-09, Vol.331, p.134-147
Hauptverfasser:	Trimpe, Darcy M, Byrd-Jacobs, Christine A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - pathology Adult Stem Cells - physiology Aging - pathology Aging - physiology Animals Bromodeoxyuridine Caspase 3 - metabolism Cell Movement - physiology Cell Proliferation - physiology Cell Survival - physiology Danio rerio deafferentation Female Immunohistochemistry Male Models, Animal Neural Pathways - pathology Neural Pathways - physiopathology Neural Stem Cells - pathology Neural Stem Cells - physiology neurogenesis Neurogenesis - physiology Neurology Neuronal Plasticity - physiology olfactory bulb Olfactory Bulb - pathology Olfactory Bulb - physiopathology reafferentation teleost Zebrafish
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Zusammenfassung:	Highlights • Reversible deafferentation affects cell genesis in the olfactory bulbs of zebrafish. • Chronic deafferentation increases new cell migration into both olfactory bulbs. • Most new cells that enter the olfactory bulb during deafferentation do not survive. • Reafferentation sustains increased cell migration and few new cells become neurons. • Recovery of input increases survival of new cells in the olfactory bulbs of zebrafish.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.06.026