Patient Age and Hip Morphology Alter Joint Mechanics in Computational Models of Patients With Hip Dysplasia

Older patients (> 30 years) undergoing periacetabular osteotomy (PAO) to delay THA often have inferior patient-reported outcomes than younger adult patients (< 30 years). It is unclear how patient age affects hip morphology, mechanics, or patient-reported outcome scores. (1) Is increased patient age associated with computationally derived elevations in joint contact stresses? (2) Does hip shape affect computationally derived joint contact stresses? (3) Do computationally derived joint contact stresses correlate with visual analog scale (VAS) pain scores evaluated at rest in the clinic at a minimum of 1 year after surgery? A minimum of 1 year of clinical followup was required for inclusion. The first 15 patients younger than 30 years of age, and the first 15 patients older than 30 years of age, who underwent PAO for treatment of classic dysplasia (lateral center-edge angle < 25°) who met the minimum followup were selected from a historical database of patients treated by a single surgeon between April 2003 and April 2010. The older cohort consisted of 14 females and one male with a median age of 41 years (range, 31-54 years). The younger cohort consisted of 10 females and five males with a median age of 19 years (range, 12-29 years). Median followup for the older than 30 years versus younger than 30 years cohort was 19 months (range, 12-37 months) versus 24 months (range, 13-38 months). Pre- and postoperative hip models were created from CT scans for discrete element analysis (DEA) contact stress computations. DEA treats contacting articular surfaces as rigid bodies (bones) separated by a bed of compressive springs (cartilage), the deformation of which governs computation of joint contact stresses. This technique greatly simplifies computational complexity compared with other modeling techniques, which permits patient-specific modeling of larger cohorts. Articular surface shape was assessed by total root mean square deviation of each patient's acetabular and femoral cartilage geometry from sphericity. Preoperative and postoperative VAS pain scores evaluated at rest in the clinic were correlated with computed contact stresses. Patients older than 30 years had higher predicted median peak contact stress preoperatively (13 MPa [range, 9-23 MPa; 95% confidence interval {CI}, 11-15 MPa] versus 7 MPa [range, 6-14 MPa; 95% CI, 6-8 MPa], p < 0.001) but not postoperatively (10 MPa [range, 6-18 MPa; 95% CI, 8-12 MPa] versus 8 MPa [range, 6-13 MPa; 95% CI, 7-9 MPa], p