Association between Nonalcoholic Fatty Liver Disease at CT and Coronary Microvascular Dysfunction at Myocardial Perfusion PET/CT

Background Cardiovascular disease is a major cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD). However, the association of NAFLD with coronary microvascular dysfunction is, to our knowledge, unknown. Purpose To determine whether coronary microvascular dysfunction is more...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Radiology 2019-05, Vol.291 (2), p.330-337
Hauptverfasser: Vita, Tomas, Murphy, David J, Osborne, Michael T, Bajaj, Navkaranbir S, Keraliya, Abhishek, Jacob, Sophia, Diaz Martinez, Angel Joel, Nodoushani, Ariana, Bravo, Paco, Hainer, Jon, Bibbo, Courtney F, Steigner, Michael L, Taqueti, Viviany R, Skali, Hicham, Blankstein, Ron, Di Carli, Marcelo F, Dorbala, Sharmila
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 337
container_issue 2
container_start_page 330
container_title Radiology
container_volume 291
creator Vita, Tomas
Murphy, David J
Osborne, Michael T
Bajaj, Navkaranbir S
Keraliya, Abhishek
Jacob, Sophia
Diaz Martinez, Angel Joel
Nodoushani, Ariana
Bravo, Paco
Hainer, Jon
Bibbo, Courtney F
Steigner, Michael L
Taqueti, Viviany R
Skali, Hicham
Blankstein, Ron
Di Carli, Marcelo F
Dorbala, Sharmila
description Background Cardiovascular disease is a major cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD). However, the association of NAFLD with coronary microvascular dysfunction is, to our knowledge, unknown. Purpose To determine whether coronary microvascular dysfunction is more prevalent in patients with NAFLD and to determine whether coronary microvascular dysfunction predicts major adverse cardiac events (MACE) independently of NAFLD. Materials and Methods This retrospective study (2006-2014) included patients without evidence of obstructive epicardial coronary artery disease and healthy left ventricular ejection fraction (≥40%) at a clinical rest and stress myocardial perfusion PET/CT. NAFLD was defined by a mean hepatic attenuation of less than 40 HU at CT and coronary microvascular dysfunction as a coronary flow reserve (CFR) of less than 2.0. A composite of all-cause mortality, myocardial infarction, coronary revascularization, and hospitalization because of heart failure comprised MACE (130 of 886 patients; 14.7%). The relation between NAFLD and MACE was assessed by using multivariable Cox regression analysis. Results Among 886 patients (mean age, 62 years ± 12 [standard deviation]; 631 women [mean age, 62 years ± 12 years] and 255 men [mean age, 61 years ± 12]; and ejection fraction, 63% ± 9), 125 patients (14.1%) had NAFLD and 411 patients (46.4%) had coronary microvascular dysfunction. Coronary microvascular dysfunction was more prevalent (64.8% vs 43.4%; < .001) and CFR was lower (1.9 ± 1.1 vs 2.2 ± 0.7; < .001) in patients with NAFLD compared with those without NAFLD. NAFLD independently predicted coronary microvascular dysfunction ( = .01). The interaction of NAFLD and male sex predicted MACE (hazard ratio, 1.45; 95% confidence interval: 1.08, 1.69; = .008) and coronary microvascular dysfunction remained associated with MACE (adjusted hazard ratio, 1.46; 95% confidence interval: 1.02, 2.07; = .04). Conclusion Coronary microvascular dysfunction was more prevalent in patients with nonalcoholic fatty liver disease and predicted major adverse cardiac events independently of nonalcoholic fatty liver disease. © RSNA, 2019 See also the editorial by Ambale-Venkatesh and Lima in this issue.
doi_str_mv 10.1148/radiol.2019181793
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6492883</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2188211239</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-8f7e62758c24a379c419b21b5cdc121ea70c46eb45b8ad70763f1690825030143</originalsourceid><addsrcrecordid>eNpVkU1v1DAQhi0EotvCD-CCfOSS1mPHsXNBqtKWIm2hh-VsTRyHGnnjYieL9sZPx2VLgdNIM8-88_ES8gbYKUCtzxIOPoZTzqAFDaoVz8gKJFcVCJDPyYoxISpdQ3tEjnP-xhjUUquX5EgwLSRovSI_z3OO1uPs40R7N_9wbqKf4oTBxrsYvKVXOM97uvY7l-iFzw6zozjTbkNxGmgXU4HTnt54m-IOs10CFnCfx2Wyv1ULfLOPFtPgMdBbl8YlP-RvLzdn3eYVeTFiyO71YzwhX64uN911tf784WN3vq5s3ci50qNyDVdSW16jUK0tV_UcemkHCxwcKlZA19ey1zgophoxQtMyzSUT5W5xQt4fdO-XfusG66Y5YTD3yW_L-iaiN_9XJn9nvsadaeqWay2KwLtHgRS_Ly7PZuuzdSHg5OKSDS__5ABctAWFA1peknNy49MYYObBOXNwzvx1rvS8_Xe_p44_VolfbT6XrQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2188211239</pqid></control><display><type>article</type><title>Association between Nonalcoholic Fatty Liver Disease at CT and Coronary Microvascular Dysfunction at Myocardial Perfusion PET/CT</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Radiological Society of North America</source><creator>Vita, Tomas ; Murphy, David J ; Osborne, Michael T ; Bajaj, Navkaranbir S ; Keraliya, Abhishek ; Jacob, Sophia ; Diaz Martinez, Angel Joel ; Nodoushani, Ariana ; Bravo, Paco ; Hainer, Jon ; Bibbo, Courtney F ; Steigner, Michael L ; Taqueti, Viviany R ; Skali, Hicham ; Blankstein, Ron ; Di Carli, Marcelo F ; Dorbala, Sharmila</creator><creatorcontrib>Vita, Tomas ; Murphy, David J ; Osborne, Michael T ; Bajaj, Navkaranbir S ; Keraliya, Abhishek ; Jacob, Sophia ; Diaz Martinez, Angel Joel ; Nodoushani, Ariana ; Bravo, Paco ; Hainer, Jon ; Bibbo, Courtney F ; Steigner, Michael L ; Taqueti, Viviany R ; Skali, Hicham ; Blankstein, Ron ; Di Carli, Marcelo F ; Dorbala, Sharmila</creatorcontrib><description>Background Cardiovascular disease is a major cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD). However, the association of NAFLD with coronary microvascular dysfunction is, to our knowledge, unknown. Purpose To determine whether coronary microvascular dysfunction is more prevalent in patients with NAFLD and to determine whether coronary microvascular dysfunction predicts major adverse cardiac events (MACE) independently of NAFLD. Materials and Methods This retrospective study (2006-2014) included patients without evidence of obstructive epicardial coronary artery disease and healthy left ventricular ejection fraction (≥40%) at a clinical rest and stress myocardial perfusion PET/CT. NAFLD was defined by a mean hepatic attenuation of less than 40 HU at CT and coronary microvascular dysfunction as a coronary flow reserve (CFR) of less than 2.0. A composite of all-cause mortality, myocardial infarction, coronary revascularization, and hospitalization because of heart failure comprised MACE (130 of 886 patients; 14.7%). The relation between NAFLD and MACE was assessed by using multivariable Cox regression analysis. Results Among 886 patients (mean age, 62 years ± 12 [standard deviation]; 631 women [mean age, 62 years ± 12 years] and 255 men [mean age, 61 years ± 12]; and ejection fraction, 63% ± 9), 125 patients (14.1%) had NAFLD and 411 patients (46.4%) had coronary microvascular dysfunction. Coronary microvascular dysfunction was more prevalent (64.8% vs 43.4%; &lt; .001) and CFR was lower (1.9 ± 1.1 vs 2.2 ± 0.7; &lt; .001) in patients with NAFLD compared with those without NAFLD. NAFLD independently predicted coronary microvascular dysfunction ( = .01). The interaction of NAFLD and male sex predicted MACE (hazard ratio, 1.45; 95% confidence interval: 1.08, 1.69; = .008) and coronary microvascular dysfunction remained associated with MACE (adjusted hazard ratio, 1.46; 95% confidence interval: 1.02, 2.07; = .04). Conclusion Coronary microvascular dysfunction was more prevalent in patients with nonalcoholic fatty liver disease and predicted major adverse cardiac events independently of nonalcoholic fatty liver disease. © RSNA, 2019 See also the editorial by Ambale-Venkatesh and Lima in this issue.</description><identifier>ISSN: 0033-8419</identifier><identifier>EISSN: 1527-1315</identifier><identifier>DOI: 10.1148/radiol.2019181793</identifier><identifier>PMID: 30835188</identifier><language>eng</language><publisher>United States: Radiological Society of North America</publisher><subject>Aged ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - physiopathology ; Female ; Humans ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease - diagnostic imaging ; Non-alcoholic Fatty Liver Disease - epidemiology ; Original Research ; Positron Emission Tomography Computed Tomography ; Retrospective Studies ; Risk Factors</subject><ispartof>Radiology, 2019-05, Vol.291 (2), p.330-337</ispartof><rights>2019 by the Radiological Society of North America, Inc. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-8f7e62758c24a379c419b21b5cdc121ea70c46eb45b8ad70763f1690825030143</citedby><cites>FETCH-LOGICAL-c465t-8f7e62758c24a379c419b21b5cdc121ea70c46eb45b8ad70763f1690825030143</cites><orcidid>0000-0003-1462-1185 ; 0000-0003-1001-1718 ; 0000-0002-4605-0797 ; 0000-0002-0361-672X ; 0000-0003-2937-0622 ; 0000-0002-3742-4267 ; 0000-0001-6733-0184 ; 0000-0002-5629-4138 ; 0000-0002-0022-4376 ; 0000-0001-7850-8144 ; 0000-0002-0572-912X ; 0000-0002-0136-3781</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4016,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30835188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vita, Tomas</creatorcontrib><creatorcontrib>Murphy, David J</creatorcontrib><creatorcontrib>Osborne, Michael T</creatorcontrib><creatorcontrib>Bajaj, Navkaranbir S</creatorcontrib><creatorcontrib>Keraliya, Abhishek</creatorcontrib><creatorcontrib>Jacob, Sophia</creatorcontrib><creatorcontrib>Diaz Martinez, Angel Joel</creatorcontrib><creatorcontrib>Nodoushani, Ariana</creatorcontrib><creatorcontrib>Bravo, Paco</creatorcontrib><creatorcontrib>Hainer, Jon</creatorcontrib><creatorcontrib>Bibbo, Courtney F</creatorcontrib><creatorcontrib>Steigner, Michael L</creatorcontrib><creatorcontrib>Taqueti, Viviany R</creatorcontrib><creatorcontrib>Skali, Hicham</creatorcontrib><creatorcontrib>Blankstein, Ron</creatorcontrib><creatorcontrib>Di Carli, Marcelo F</creatorcontrib><creatorcontrib>Dorbala, Sharmila</creatorcontrib><title>Association between Nonalcoholic Fatty Liver Disease at CT and Coronary Microvascular Dysfunction at Myocardial Perfusion PET/CT</title><title>Radiology</title><addtitle>Radiology</addtitle><description>Background Cardiovascular disease is a major cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD). However, the association of NAFLD with coronary microvascular dysfunction is, to our knowledge, unknown. Purpose To determine whether coronary microvascular dysfunction is more prevalent in patients with NAFLD and to determine whether coronary microvascular dysfunction predicts major adverse cardiac events (MACE) independently of NAFLD. Materials and Methods This retrospective study (2006-2014) included patients without evidence of obstructive epicardial coronary artery disease and healthy left ventricular ejection fraction (≥40%) at a clinical rest and stress myocardial perfusion PET/CT. NAFLD was defined by a mean hepatic attenuation of less than 40 HU at CT and coronary microvascular dysfunction as a coronary flow reserve (CFR) of less than 2.0. A composite of all-cause mortality, myocardial infarction, coronary revascularization, and hospitalization because of heart failure comprised MACE (130 of 886 patients; 14.7%). The relation between NAFLD and MACE was assessed by using multivariable Cox regression analysis. Results Among 886 patients (mean age, 62 years ± 12 [standard deviation]; 631 women [mean age, 62 years ± 12 years] and 255 men [mean age, 61 years ± 12]; and ejection fraction, 63% ± 9), 125 patients (14.1%) had NAFLD and 411 patients (46.4%) had coronary microvascular dysfunction. Coronary microvascular dysfunction was more prevalent (64.8% vs 43.4%; &lt; .001) and CFR was lower (1.9 ± 1.1 vs 2.2 ± 0.7; &lt; .001) in patients with NAFLD compared with those without NAFLD. NAFLD independently predicted coronary microvascular dysfunction ( = .01). The interaction of NAFLD and male sex predicted MACE (hazard ratio, 1.45; 95% confidence interval: 1.08, 1.69; = .008) and coronary microvascular dysfunction remained associated with MACE (adjusted hazard ratio, 1.46; 95% confidence interval: 1.02, 2.07; = .04). Conclusion Coronary microvascular dysfunction was more prevalent in patients with nonalcoholic fatty liver disease and predicted major adverse cardiac events independently of nonalcoholic fatty liver disease. © RSNA, 2019 See also the editorial by Ambale-Venkatesh and Lima in this issue.</description><subject>Aged</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-alcoholic Fatty Liver Disease - diagnostic imaging</subject><subject>Non-alcoholic Fatty Liver Disease - epidemiology</subject><subject>Original Research</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>0033-8419</issn><issn>1527-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v1DAQhi0EotvCD-CCfOSS1mPHsXNBqtKWIm2hh-VsTRyHGnnjYieL9sZPx2VLgdNIM8-88_ES8gbYKUCtzxIOPoZTzqAFDaoVz8gKJFcVCJDPyYoxISpdQ3tEjnP-xhjUUquX5EgwLSRovSI_z3OO1uPs40R7N_9wbqKf4oTBxrsYvKVXOM97uvY7l-iFzw6zozjTbkNxGmgXU4HTnt54m-IOs10CFnCfx2Wyv1ULfLOPFtPgMdBbl8YlP-RvLzdn3eYVeTFiyO71YzwhX64uN911tf784WN3vq5s3ci50qNyDVdSW16jUK0tV_UcemkHCxwcKlZA19ey1zgophoxQtMyzSUT5W5xQt4fdO-XfusG66Y5YTD3yW_L-iaiN_9XJn9nvsadaeqWay2KwLtHgRS_Ly7PZuuzdSHg5OKSDS__5ABctAWFA1peknNy49MYYObBOXNwzvx1rvS8_Xe_p44_VolfbT6XrQ</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Vita, Tomas</creator><creator>Murphy, David J</creator><creator>Osborne, Michael T</creator><creator>Bajaj, Navkaranbir S</creator><creator>Keraliya, Abhishek</creator><creator>Jacob, Sophia</creator><creator>Diaz Martinez, Angel Joel</creator><creator>Nodoushani, Ariana</creator><creator>Bravo, Paco</creator><creator>Hainer, Jon</creator><creator>Bibbo, Courtney F</creator><creator>Steigner, Michael L</creator><creator>Taqueti, Viviany R</creator><creator>Skali, Hicham</creator><creator>Blankstein, Ron</creator><creator>Di Carli, Marcelo F</creator><creator>Dorbala, Sharmila</creator><general>Radiological Society of North America</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1462-1185</orcidid><orcidid>https://orcid.org/0000-0003-1001-1718</orcidid><orcidid>https://orcid.org/0000-0002-4605-0797</orcidid><orcidid>https://orcid.org/0000-0002-0361-672X</orcidid><orcidid>https://orcid.org/0000-0003-2937-0622</orcidid><orcidid>https://orcid.org/0000-0002-3742-4267</orcidid><orcidid>https://orcid.org/0000-0001-6733-0184</orcidid><orcidid>https://orcid.org/0000-0002-5629-4138</orcidid><orcidid>https://orcid.org/0000-0002-0022-4376</orcidid><orcidid>https://orcid.org/0000-0001-7850-8144</orcidid><orcidid>https://orcid.org/0000-0002-0572-912X</orcidid><orcidid>https://orcid.org/0000-0002-0136-3781</orcidid></search><sort><creationdate>20190501</creationdate><title>Association between Nonalcoholic Fatty Liver Disease at CT and Coronary Microvascular Dysfunction at Myocardial Perfusion PET/CT</title><author>Vita, Tomas ; Murphy, David J ; Osborne, Michael T ; Bajaj, Navkaranbir S ; Keraliya, Abhishek ; Jacob, Sophia ; Diaz Martinez, Angel Joel ; Nodoushani, Ariana ; Bravo, Paco ; Hainer, Jon ; Bibbo, Courtney F ; Steigner, Michael L ; Taqueti, Viviany R ; Skali, Hicham ; Blankstein, Ron ; Di Carli, Marcelo F ; Dorbala, Sharmila</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-8f7e62758c24a379c419b21b5cdc121ea70c46eb45b8ad70763f1690825030143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Non-alcoholic Fatty Liver Disease - diagnostic imaging</topic><topic>Non-alcoholic Fatty Liver Disease - epidemiology</topic><topic>Original Research</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vita, Tomas</creatorcontrib><creatorcontrib>Murphy, David J</creatorcontrib><creatorcontrib>Osborne, Michael T</creatorcontrib><creatorcontrib>Bajaj, Navkaranbir S</creatorcontrib><creatorcontrib>Keraliya, Abhishek</creatorcontrib><creatorcontrib>Jacob, Sophia</creatorcontrib><creatorcontrib>Diaz Martinez, Angel Joel</creatorcontrib><creatorcontrib>Nodoushani, Ariana</creatorcontrib><creatorcontrib>Bravo, Paco</creatorcontrib><creatorcontrib>Hainer, Jon</creatorcontrib><creatorcontrib>Bibbo, Courtney F</creatorcontrib><creatorcontrib>Steigner, Michael L</creatorcontrib><creatorcontrib>Taqueti, Viviany R</creatorcontrib><creatorcontrib>Skali, Hicham</creatorcontrib><creatorcontrib>Blankstein, Ron</creatorcontrib><creatorcontrib>Di Carli, Marcelo F</creatorcontrib><creatorcontrib>Dorbala, Sharmila</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vita, Tomas</au><au>Murphy, David J</au><au>Osborne, Michael T</au><au>Bajaj, Navkaranbir S</au><au>Keraliya, Abhishek</au><au>Jacob, Sophia</au><au>Diaz Martinez, Angel Joel</au><au>Nodoushani, Ariana</au><au>Bravo, Paco</au><au>Hainer, Jon</au><au>Bibbo, Courtney F</au><au>Steigner, Michael L</au><au>Taqueti, Viviany R</au><au>Skali, Hicham</au><au>Blankstein, Ron</au><au>Di Carli, Marcelo F</au><au>Dorbala, Sharmila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Nonalcoholic Fatty Liver Disease at CT and Coronary Microvascular Dysfunction at Myocardial Perfusion PET/CT</atitle><jtitle>Radiology</jtitle><addtitle>Radiology</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>291</volume><issue>2</issue><spage>330</spage><epage>337</epage><pages>330-337</pages><issn>0033-8419</issn><eissn>1527-1315</eissn><abstract>Background Cardiovascular disease is a major cause of mortality in patients with nonalcoholic fatty liver disease (NAFLD). However, the association of NAFLD with coronary microvascular dysfunction is, to our knowledge, unknown. Purpose To determine whether coronary microvascular dysfunction is more prevalent in patients with NAFLD and to determine whether coronary microvascular dysfunction predicts major adverse cardiac events (MACE) independently of NAFLD. Materials and Methods This retrospective study (2006-2014) included patients without evidence of obstructive epicardial coronary artery disease and healthy left ventricular ejection fraction (≥40%) at a clinical rest and stress myocardial perfusion PET/CT. NAFLD was defined by a mean hepatic attenuation of less than 40 HU at CT and coronary microvascular dysfunction as a coronary flow reserve (CFR) of less than 2.0. A composite of all-cause mortality, myocardial infarction, coronary revascularization, and hospitalization because of heart failure comprised MACE (130 of 886 patients; 14.7%). The relation between NAFLD and MACE was assessed by using multivariable Cox regression analysis. Results Among 886 patients (mean age, 62 years ± 12 [standard deviation]; 631 women [mean age, 62 years ± 12 years] and 255 men [mean age, 61 years ± 12]; and ejection fraction, 63% ± 9), 125 patients (14.1%) had NAFLD and 411 patients (46.4%) had coronary microvascular dysfunction. Coronary microvascular dysfunction was more prevalent (64.8% vs 43.4%; &lt; .001) and CFR was lower (1.9 ± 1.1 vs 2.2 ± 0.7; &lt; .001) in patients with NAFLD compared with those without NAFLD. NAFLD independently predicted coronary microvascular dysfunction ( = .01). The interaction of NAFLD and male sex predicted MACE (hazard ratio, 1.45; 95% confidence interval: 1.08, 1.69; = .008) and coronary microvascular dysfunction remained associated with MACE (adjusted hazard ratio, 1.46; 95% confidence interval: 1.02, 2.07; = .04). Conclusion Coronary microvascular dysfunction was more prevalent in patients with nonalcoholic fatty liver disease and predicted major adverse cardiac events independently of nonalcoholic fatty liver disease. © RSNA, 2019 See also the editorial by Ambale-Venkatesh and Lima in this issue.</abstract><cop>United States</cop><pub>Radiological Society of North America</pub><pmid>30835188</pmid><doi>10.1148/radiol.2019181793</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1462-1185</orcidid><orcidid>https://orcid.org/0000-0003-1001-1718</orcidid><orcidid>https://orcid.org/0000-0002-4605-0797</orcidid><orcidid>https://orcid.org/0000-0002-0361-672X</orcidid><orcidid>https://orcid.org/0000-0003-2937-0622</orcidid><orcidid>https://orcid.org/0000-0002-3742-4267</orcidid><orcidid>https://orcid.org/0000-0001-6733-0184</orcidid><orcidid>https://orcid.org/0000-0002-5629-4138</orcidid><orcidid>https://orcid.org/0000-0002-0022-4376</orcidid><orcidid>https://orcid.org/0000-0001-7850-8144</orcidid><orcidid>https://orcid.org/0000-0002-0572-912X</orcidid><orcidid>https://orcid.org/0000-0002-0136-3781</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0033-8419
ispartof Radiology, 2019-05, Vol.291 (2), p.330-337
issn 0033-8419
1527-1315
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6492883
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Radiological Society of North America
subjects Aged
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary Artery Disease - physiopathology
Female
Humans
Male
Middle Aged
Non-alcoholic Fatty Liver Disease - diagnostic imaging
Non-alcoholic Fatty Liver Disease - epidemiology
Original Research
Positron Emission Tomography Computed Tomography
Retrospective Studies
Risk Factors
title Association between Nonalcoholic Fatty Liver Disease at CT and Coronary Microvascular Dysfunction at Myocardial Perfusion PET/CT
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T04%3A27%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20Nonalcoholic%20Fatty%20Liver%20Disease%20at%20CT%20and%20Coronary%20Microvascular%20Dysfunction%20at%20Myocardial%20Perfusion%20PET/CT&rft.jtitle=Radiology&rft.au=Vita,%20Tomas&rft.date=2019-05-01&rft.volume=291&rft.issue=2&rft.spage=330&rft.epage=337&rft.pages=330-337&rft.issn=0033-8419&rft.eissn=1527-1315&rft_id=info:doi/10.1148/radiol.2019181793&rft_dat=%3Cproquest_pubme%3E2188211239%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2188211239&rft_id=info:pmid/30835188&rfr_iscdi=true