Effect of chronic p , p ′-dichlorodiphenyldichloroethylene (DDE) exposure on high fat diet-induced alterations in glucose and lipid metabolism in male C57BL/6H mice
Highlights • Chronic DDE exposure in conjunction with high fat diet (HFD) had a biphasic effect on fasting blood glucose. • Prolonged DDE exposure decreased HFD-induced glucose intolerance, hyperinsulinemia, and homeostasis model assessment value for insulin resistance (HOMA-IR). • Chronic DDE expos...
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Veröffentlicht in: | Toxicology (Amsterdam) 2015-02, Vol.328, p.112-122 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Highlights • Chronic DDE exposure in conjunction with high fat diet (HFD) had a biphasic effect on fasting blood glucose. • Prolonged DDE exposure decreased HFD-induced glucose intolerance, hyperinsulinemia, and homeostasis model assessment value for insulin resistance (HOMA-IR). • Chronic DDE exposure in conjunction with HFD increased skeletal muscle but not adipose tissue Glut4 expression compared to HFD alone. • HFD-induced hepatic steatosis is reduced by prolonged, chronic DDE exposure. |
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ISSN: | 0300-483X 1879-3185 |
DOI: | 10.1016/j.tox.2014.12.017 |