Sex‐related differences in left ventricular diastolic function and arterial elastance during admission in patients with heart failure with preserved ejection fraction: The PURSUIT HFpEF study

Sex‐related differences in left ventricular diastolic function and arterial elastance during admission in patients with heart failure with preserved ejection fraction: The PURSUIT HFpEF study

Background We previously reported that an index of afterload‐related left ventricular diastolic function, operant diastolic elastance (Ed)/effective arterial elastance (Ea) = E/e’/(0.9 × systolic blood pressure), was significantly higher in elderly hypertensive women. We aimed to determine sex‐relat...

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Veröffentlicht in:Clinical cardiology (Mahwah, N.J.) N.J.), 2018-12, Vol.41 (12), p.1529-1536
Hauptverfasser: Hoshida, Shiro, Watanabe, Tetsuya, Shinoda, Yukinori, Ikeoka, Kuniyasu, Minamisaka, Tomoko, Fukuoka, Hidetada, Inui, Hirooki, Ueno, Keisuke, Suna, Shinichiro, Nakatani, Daisaku, Hikoso, Shungo, Yamada, Takahisa, Yasumura, Yoshio, Fuji, Hisakazu, Sakata, Yasushi, Tamaki, Shunsuke, Fukunami, Masatake, Hayashi, Takaharu, Takeda, Yasuharu, Higuchi, Yoshiharu, Masuda, Masaharu, Asai, Mitsutoshi, Mano, Toshiaki, Takeda, Yoshihiro, Nagai, Yoshiyuki, Yamashita, Shizuya, Nakagawa, Yusuke, Nozaki, Shuichi, Abe, Haruhiko, Ueda, Yasunori, Uematsu, Masaaki, Koretsune, Yukihiro, Nagai, Kunihiko, Yano, Masamichi, Nishino, Masami, Tanouchi, Jun, Segawa, Takatsugu, Hasegawa, Shinji, Yoshima, Syouhei, Ichikawa, Minoru, Kijima, Yoshiyuki, Rin, Eisai, Izumi, Masahiro, Yamamoto, Hiroyoshi, Kato, Hiroyasu, Nakatani, Kazuhiro, Hiraoka, Hisatoyo, Hirooka, Keiji, Nishio, Mayu, Yoshimura, Takahiro, Okuyama, Yuji, Sasaki, Tatsuya, Tani, Akihiro, Okumoto, Yasushi, Akagi, Hideharu, Makino, Yasunaka, Iwakura, Katsuomi, Takano, Yuzuru, Nishikawa, Nagahiro, Kitao, Takashi, Kanai, Hideyuki, Shioyama, Wataru, Mukai, Mikio, Fujita, Masashi, Harada, Koichiro, Nakagawa, Osamu, Araki, Ryo, Yamada, Takayuki, Sera, Fusako, Nakamoto, Kei, Tsukamoto, Yasumasa, Toshinari, Onishi, Kioka, Hidetaka, Ohtani, Tomohito, Mizuno, Hiroya, Kojima, Takayuki, Dohi, Tomoharu, Takeda, Toshihiro, Nakagawa, Akito, Matsumura, Yasushi
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aged, 80 and over
arterial elastance
Arteries - physiopathology
Blood Pressure
Clinical Investigations
Diastole
diastolic function
Echocardiography, Doppler
Ejection fraction
elderly
Female
Gender differences
Heart failure
Heart Failure - diagnosis
Heart Failure - epidemiology
Heart Failure - physiopathology
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Incidence
Japan - epidemiology
left cardiac volume
Male
Patient Admission
Prospective Studies
sex
Sex Factors
Stroke Volume - physiology
Vascular Resistance - physiology
Ventricular Function, Left - physiology
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Zusammenfassung:Background We previously reported that an index of afterload‐related left ventricular diastolic function, operant diastolic elastance (Ed)/effective arterial elastance (Ea) = E/e’/(0.9 × systolic blood pressure), was significantly higher in elderly hypertensive women. We aimed to determine sex‐related differences in the E/e’‐related indices for left ventricular diastolic function and their related factors during admission in patients with heart failure with preserved ejection fraction (HFpEF). Hypothesis Elderly HFpEF women exhibit severe left ventricular diastolic dysfunction associated with different left atrioventricular volume ratio. Methods We divided 267 patients with HFpEF (men/women, 116/151) into two groups by age (≥75 years, n = 212;
ISSN:0160-9289
1932-8737
DOI:10.1002/clc.23073