Glomerular filtration rate: A prognostic marker in atrial fibrillation—A subanalysis of the AntiThrombotic Agents Atrial Fibrillation

Objective An increased cardiovascular mortality and morbidity has been widely reported in patients with atrial fibrillation (AF). In this study, a subanalysis of the AntiThrombotic Agents Atrial Fibrillation (ATA‐AF) is performed with the aim to evaluate estimated glomerular filtration rate (eGFR) a...

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Veröffentlicht in:	Clinical cardiology (Mahwah, N.J.) N.J.), 2018-12, Vol.41 (12), p.1570-1577
Hauptverfasser:	Pizzimenti, Giovanni, Ledda, Antonietta, Lencioni, Mauro, Gunnellini, MG, Molini, G, Massarelli, L, Candelmo, F, Perlangeli, S, Masina, M, Bertinieri, G, Zaccaroni, S, Marchetti, G, Colletta, M, Capretti, M, Ganga, R, Caddori, A, Musacchio, E, Stendardo, A, Bassano, F, Piccinni, GC, De Caro, G, Losi, E, Cascio Ingurgio, N, Gulizia, MM, Quattrini, C, Calcagno, S, Pastorelli, R, Migliacci, R, Bertolazzi, S, Fenoglio, L, Ziacchi, V, Zipoli, A, Scattolin, G, Tavernese, G, Goedecke, L, Ranieri, AT, Zanini, G, Lo, G, Moroni, LA, Costa, S, Esposito, L, Cuzzucrea, DG, Selva, E, Porrino, L, Corsini, F, Morando, G, Palumbo, G, La Torre, PPA, Borrello, VM, Malavasi, V, Divella, C, Gallucci, F, Cannavale, A, Bresciani, A, Zuccoli, A, Barbieri, E, Rossi, A, Sanna, P, Salvati, F, Giordano, G, Pellegrini, F, Pighini, G, Ledda, A, Enia, F, Aloisi, B, Di Marco, S, Ginocchio, G, Tintori, G, Manini, M, Pastore, A, Spirito, G, Querci, F, Molero, U, D'Arienzo, E, Pulitanò, G, Iori, I, Conversano, L, Santini, M, Fedele, F, Zamboni, S, De Benedictis, M, Anselmi, M, Celino, T, Nassi, R, Fronticelli Baldelli, M, Petacchi, R, Maninchedda, P, Menardo, G, Bartone, B, La Brocca, A, Pirozzi, MR, Beato, E, Biscottini, B, Coser, A, Masi De Luca, G De, Vitali Serdoz, L, Salerno Uriarte, JA, Levantesi, G, Olivetti, P, Muriago, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged atrial fibrillation Atrial Fibrillation - diagnosis Atrial Fibrillation - drug therapy Atrial Fibrillation - epidemiology Cardiac arrhythmia Clinical Investigations Female Fibrinolytic Agents - therapeutic use Follow-Up Studies glomerular filtration rate Glomerular Filtration Rate - physiology Humans Incidence Italy - epidemiology Male Morbidity - trends Mortality Patients Prognosis Renal Insufficiency - epidemiology Renal Insufficiency - etiology Renal Insufficiency - physiopathology Retrospective Studies Risk Assessment - methods Risk Factors Survival Rate - trends Time Factors
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Zusammenfassung:	Objective An increased cardiovascular mortality and morbidity has been widely reported in patients with atrial fibrillation (AF). In this study, a subanalysis of the AntiThrombotic Agents Atrial Fibrillation (ATA‐AF) is performed with the aim to evaluate estimated glomerular filtration rate (eGFR) as an independent prognostic marker of cardiovascular mortality and morbidity in patients with AF. Methods and Results The ATA‐AF study enrolled 7148 patients with AF, in 360 Italian centers. The eGFR was calculated from data reported in patient notes or hospital database. This post‐hoc analysis included 1097 AF patients with eGFR data available and 1‐year clinical follow‐up. The endpoint was assessed as cardiovascular mortality and/or hospital admission for cardiovascular causes at follow‐up. Patients were also divided in two groups according to the eGFR (
ISSN:	0160-9289 1932-8737
DOI:	10.1002/clc.23065