Modulation of immune development and function by intestinal microbiota

Highlights • The microbiota has a fundamental role in local and systemic immunity and homeostasis. • Interactions involving microbiota, epithelial cells, and leukocytes enforce homeostasis. • Microbial cues (PRR agonists and metabolites) regulate immune development and function. • Microbiota elicit...

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Veröffentlicht in:	Trends in immunology 2014-11, Vol.35 (11), p.507-517
Hauptverfasser:	Kabat, Agnieszka M, Srinivasan, Naren, Maloy, Kevin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibiotics Bacteria Cell Differentiation commensals Disease Homeostasis Humans immune regulation Immune system Immunity, Innate Immunity, Mucosal Immunoglobulin A, Secretory - biosynthesis Immunoglobulin A, Secretory - immunology Immunomodulation Inflammatory bowel disease Inflammatory diseases Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestines - immunology Intestines - microbiology Lymphocytes Lymphocytes - cytology Lymphocytes - immunology Lymphocytes - metabolism Metabolic disorders Metabolites Microbiota mucosal immunity Nosocomial infections Phagocytes - immunology Phagocytes - metabolism Phagocytes - microbiology Signal Transduction
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Beschreibung
Zusammenfassung:	Highlights • The microbiota has a fundamental role in local and systemic immunity and homeostasis. • Interactions involving microbiota, epithelial cells, and leukocytes enforce homeostasis. • Microbial cues (PRR agonists and metabolites) regulate immune development and function. • Microbiota elicit both host-protective and anti-inflammatory T and B cell responses.
ISSN:	1471-4906 1471-4981
DOI:	10.1016/j.it.2014.07.010