Characterization of a cryptic IGH/CCND1 rearrangement in a case of mantle cell lymphoma with negative CCND1 FISH studies

•This article characterizes a cryptic IGH/CCND1 rearrangement in MCL by NGS.•Mate-pair sequencing can help in accurately diagnosing MCL in cases of cyclin-D1–positive B-cell lymphoma with negative CCND1 FISH studies.

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Veröffentlicht in:	Blood advances 2019-04, Vol.3 (8), p.1298-1302
Hauptverfasser:	Peterson, Jess F., Baughn, Linda B., Ketterling, Rhett P., Pitel, Beth A., Smoley, Stephanie A., Vasmatzis, George, Smadbeck, James B., Greipp, Patricia T., Mangaonkar, Abhishek A., Thompson, Carrie A., Parikh, Sameer A., Chen, Dong, Viswanatha, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Exceptional Case Report Female Humans In Situ Hybridization, Fluorescence Lymphoma, Mantle-Cell - drug therapy Lymphoma, Mantle-Cell - genetics Lymphoma, Mantle-Cell - metabolism Lymphoma, Mantle-Cell - pathology Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Translocation, Genetic
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Beschreibung
Zusammenfassung:	•This article characterizes a cryptic IGH/CCND1 rearrangement in MCL by NGS.•Mate-pair sequencing can help in accurately diagnosing MCL in cases of cyclin-D1–positive B-cell lymphoma with negative CCND1 FISH studies.
ISSN:	2473-9529 2473-9537
DOI:	10.1182/bloodadvances.2019031450