Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals
Introduction. A growing number of studies have explored the association between the pretreatment lymphocyte-to-monocyte ratio (LMR) and survival outcomes in various cancers. However, its prognostic significance on bladder cancer remains inconsistent. The aim of this meta-analysis was to evaluate the...
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| description | Introduction. A growing number of studies have explored the association between the pretreatment lymphocyte-to-monocyte ratio (LMR) and survival outcomes in various cancers. However, its prognostic significance on bladder cancer remains inconsistent. The aim of this meta-analysis was to evaluate the prognostic value of pretreatment LMR in bladder cancer. Methods. The MEDLINE, EMBASE, Cochrane Library, and CNKI databases were comprehensively searched for relevant studies. A meta-analysis of overall survival (OS), recurrence-free survival (RFS), or cancer-specific survival (CSS) clinicopathological features was conducted. Results. Nine studies containing 5,638 cancer patients were analyzed in this meta-analysis. Patients with high LMR tended to have favourable OS (HR: 0.63, 95% CI: 0.50-0.80, P |
| doi_str_mv | 10.1155/2019/7593560 |
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A growing number of studies have explored the association between the pretreatment lymphocyte-to-monocyte ratio (LMR) and survival outcomes in various cancers. However, its prognostic significance on bladder cancer remains inconsistent. The aim of this meta-analysis was to evaluate the prognostic value of pretreatment LMR in bladder cancer. Methods. The MEDLINE, EMBASE, Cochrane Library, and CNKI databases were comprehensively searched for relevant studies. A meta-analysis of overall survival (OS), recurrence-free survival (RFS), or cancer-specific survival (CSS) clinicopathological features was conducted. Results. Nine studies containing 5,638 cancer patients were analyzed in this meta-analysis. Patients with high LMR tended to have favourable OS (HR: 0.63, 95% CI: 0.50-0.80, P<0.001), RFS (HR: 0.59, 95% CI: 0.38-0.91, P=0.017), and CSS (HR: 0.76, 95% CI: 0.70-0.83, P<0.001). Moreover, low LMR was highly correlated with age (≥60), differentiation (low), T stage (III-IV), lymph node metastasis (yes), and concomitant Cis (yes). Conclusion. Pretreatment LMR might be a useful predictor of survival outcomes in patients with bladder cancer.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2019/7593560</identifier><identifier>PMID: 31089397</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Aged ; Analysis ; Biomarkers, Tumor - blood ; Bladder ; Bladder cancer ; Breast cancer ; Cancer ; Cancer patients ; Cystectomy - adverse effects ; Cytotoxicity ; Female ; Humans ; Immunotherapy ; Inflammation ; Leukocyte Count ; Liver cancer ; Lymph nodes ; Lymphocytes ; Lymphocytes - pathology ; Male ; Medical prognosis ; Medical research ; Medicine, Experimental ; Meta-analysis ; Metastases ; Metastasis ; Middle Aged ; Monocytes ; Monocytes - pathology ; Neoplasm Recurrence, Local - blood ; Neoplasm Recurrence, Local - epidemiology ; Neutrophils ; Patients ; Postoperative Complications - blood ; Postoperative Complications - epidemiology ; Prognosis ; Review ; Studies ; Survival ; Survival Analysis ; Tumors ; Urinary Bladder Neoplasms - blood ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - surgery ; Urology</subject><ispartof>Disease markers, 2019-01, Vol.2019 (2019), p.1-8</ispartof><rights>Copyright © 2019 Jian-ying Ma et al.</rights><rights>COPYRIGHT 2019 John Wiley & Sons, Inc.</rights><rights>Copyright © 2019 Jian-ying Ma et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Jian-ying Ma et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-1eb1167980b5863394a46c7bba2319fe951a67e974ea13dcdeb42fd6697ceae43</citedby><cites>FETCH-LOGICAL-c499t-1eb1167980b5863394a46c7bba2319fe951a67e974ea13dcdeb42fd6697ceae43</cites><orcidid>0000-0003-1596-151X ; 0000-0001-7771-8414 ; 0000-0001-7619-118X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476040/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476040/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31089397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Corsi Romanelli, Massimiliano M.</contributor><contributor>Massimiliano M Corsi Romanelli</contributor><creatorcontrib>Ma, Jian-ying</creatorcontrib><creatorcontrib>Liu, Qin</creatorcontrib><creatorcontrib>Hu, Gang</creatorcontrib><title>Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Introduction. A growing number of studies have explored the association between the pretreatment lymphocyte-to-monocyte ratio (LMR) and survival outcomes in various cancers. However, its prognostic significance on bladder cancer remains inconsistent. The aim of this meta-analysis was to evaluate the prognostic value of pretreatment LMR in bladder cancer. Methods. The MEDLINE, EMBASE, Cochrane Library, and CNKI databases were comprehensively searched for relevant studies. A meta-analysis of overall survival (OS), recurrence-free survival (RFS), or cancer-specific survival (CSS) clinicopathological features was conducted. Results. Nine studies containing 5,638 cancer patients were analyzed in this meta-analysis. Patients with high LMR tended to have favourable OS (HR: 0.63, 95% CI: 0.50-0.80, P<0.001), RFS (HR: 0.59, 95% CI: 0.38-0.91, P=0.017), and CSS (HR: 0.76, 95% CI: 0.70-0.83, P<0.001). Moreover, low LMR was highly correlated with age (≥60), differentiation (low), T stage (III-IV), lymph node metastasis (yes), and concomitant Cis (yes). Conclusion. Pretreatment LMR might be a useful predictor of survival outcomes in patients with bladder cancer.</description><subject>Aged</subject><subject>Analysis</subject><subject>Biomarkers, Tumor - blood</subject><subject>Bladder</subject><subject>Bladder cancer</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Cystectomy - adverse effects</subject><subject>Cytotoxicity</subject><subject>Female</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Inflammation</subject><subject>Leukocyte Count</subject><subject>Liver cancer</subject><subject>Lymph nodes</subject><subject>Lymphocytes</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Meta-analysis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Monocytes</subject><subject>Monocytes - pathology</subject><subject>Neoplasm Recurrence, Local - blood</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Neutrophils</subject><subject>Patients</subject><subject>Postoperative Complications - blood</subject><subject>Postoperative Complications - epidemiology</subject><subject>Prognosis</subject><subject>Review</subject><subject>Studies</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Tumors</subject><subject>Urinary Bladder Neoplasms - blood</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary Bladder Neoplasms - surgery</subject><subject>Urology</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNks2P1CAYhxujccfVm2dD4sVE60L5Kh5Mxokfm8xGo-6ZUPq2w6YDY2HW9L_wT5Y646568gSEh-flhV9RPCb4JSGcn1WYqDPJFeUC3ykWpJa8rAXFd4sFrmRd4orhk-JBjFcYk0oxdb84oQTXiiq5KH58GkPvQ0zOoi-u965z1ngLKHQobQCtp-1uE-yUoEyhvAj-1xx9NskF5Dx6M5i2hRGt5kMjuvR50Qfn-4y0WTWg1RQT2BS20yu0RBeQTLn0Zpiii3MRLmiNzn3rrl27N0N8WNzr8gCPjuNpcfnu7dfVh3L98f35arkuLVMqlQQaQoRUNW547pYqZpiwsmlMRYnqQHFihAQlGRhCW9tCw6quFUJJCwYYPS1eH7y7fbOF1oJPoxn0bnRbM046GKf_3vFuo_twrQWTAjOcBc-OgjF820NMeuuihWEwHsI-6qqiFcaCYZXRp_-gV2E_5keYKax4RSmht1RvBtDOdyHXtbNUL0X-VkEk55l6caDsGGIcobu5MsF6DoSeA6GPgcj4kz_bvIF_JyADzw_AxvnWfHf_qYPMQGduacKkFIr-BACBx64</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Ma, Jian-ying</creator><creator>Liu, Qin</creator><creator>Hu, Gang</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1596-151X</orcidid><orcidid>https://orcid.org/0000-0001-7771-8414</orcidid><orcidid>https://orcid.org/0000-0001-7619-118X</orcidid></search><sort><creationdate>20190101</creationdate><title>Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals</title><author>Ma, Jian-ying ; Liu, Qin ; Hu, Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-1eb1167980b5863394a46c7bba2319fe951a67e974ea13dcdeb42fd6697ceae43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Analysis</topic><topic>Biomarkers, Tumor - blood</topic><topic>Bladder</topic><topic>Bladder cancer</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Cystectomy - adverse effects</topic><topic>Cytotoxicity</topic><topic>Female</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Inflammation</topic><topic>Leukocyte Count</topic><topic>Liver cancer</topic><topic>Lymph nodes</topic><topic>Lymphocytes</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Meta-analysis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Monocytes</topic><topic>Monocytes - pathology</topic><topic>Neoplasm Recurrence, Local - blood</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Neutrophils</topic><topic>Patients</topic><topic>Postoperative Complications - blood</topic><topic>Postoperative Complications - epidemiology</topic><topic>Prognosis</topic><topic>Review</topic><topic>Studies</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Tumors</topic><topic>Urinary Bladder Neoplasms - blood</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - surgery</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Jian-ying</creatorcontrib><creatorcontrib>Liu, Qin</creatorcontrib><creatorcontrib>Hu, Gang</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Jian-ying</au><au>Liu, Qin</au><au>Hu, Gang</au><au>Corsi Romanelli, Massimiliano M.</au><au>Massimiliano M Corsi Romanelli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Introduction. A growing number of studies have explored the association between the pretreatment lymphocyte-to-monocyte ratio (LMR) and survival outcomes in various cancers. However, its prognostic significance on bladder cancer remains inconsistent. The aim of this meta-analysis was to evaluate the prognostic value of pretreatment LMR in bladder cancer. Methods. The MEDLINE, EMBASE, Cochrane Library, and CNKI databases were comprehensively searched for relevant studies. A meta-analysis of overall survival (OS), recurrence-free survival (RFS), or cancer-specific survival (CSS) clinicopathological features was conducted. Results. Nine studies containing 5,638 cancer patients were analyzed in this meta-analysis. Patients with high LMR tended to have favourable OS (HR: 0.63, 95% CI: 0.50-0.80, P<0.001), RFS (HR: 0.59, 95% CI: 0.38-0.91, P=0.017), and CSS (HR: 0.76, 95% CI: 0.70-0.83, P<0.001). Moreover, low LMR was highly correlated with age (≥60), differentiation (low), T stage (III-IV), lymph node metastasis (yes), and concomitant Cis (yes). Conclusion. Pretreatment LMR might be a useful predictor of survival outcomes in patients with bladder cancer.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31089397</pmid><doi>10.1155/2019/7593560</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1596-151X</orcidid><orcidid>https://orcid.org/0000-0001-7771-8414</orcidid><orcidid>https://orcid.org/0000-0001-7619-118X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Analysis Biomarkers, Tumor - blood Bladder Bladder cancer Breast cancer Cancer Cancer patients Cystectomy - adverse effects Cytotoxicity Female Humans Immunotherapy Inflammation Leukocyte Count Liver cancer Lymph nodes Lymphocytes Lymphocytes - pathology Male Medical prognosis Medical research Medicine, Experimental Meta-analysis Metastases Metastasis Middle Aged Monocytes Monocytes - pathology Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - epidemiology Neutrophils Patients Postoperative Complications - blood Postoperative Complications - epidemiology Prognosis Review Studies Survival Survival Analysis Tumors Urinary Bladder Neoplasms - blood Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery Urology |
| title | Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals |
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