Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals

Prognostic Significance of the Lymphocyte-to-Monocyte Ratio in Bladder Cancer Undergoing Radical Cystectomy: A Meta-Analysis of 5638 Individuals

Introduction. A growing number of studies have explored the association between the pretreatment lymphocyte-to-monocyte ratio (LMR) and survival outcomes in various cancers. However, its prognostic significance on bladder cancer remains inconsistent. The aim of this meta-analysis was to evaluate the...

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Veröffentlicht in:Disease markers 2019-01, Vol.2019 (2019), p.1-8
Hauptverfasser: Ma, Jian-ying, Liu, Qin, Hu, Gang
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Analysis
Biomarkers, Tumor - blood
Bladder
Bladder cancer
Breast cancer
Cancer
Cancer patients
Cystectomy - adverse effects
Cytotoxicity
Female
Humans
Immunotherapy
Inflammation
Leukocyte Count
Liver cancer
Lymph nodes
Lymphocytes
Lymphocytes - pathology
Male
Medical prognosis
Medical research
Medicine, Experimental
Meta-analysis
Metastases
Metastasis
Middle Aged
Monocytes
Monocytes - pathology
Neoplasm Recurrence, Local - blood
Neoplasm Recurrence, Local - epidemiology
Neutrophils
Patients
Postoperative Complications - blood
Postoperative Complications - epidemiology
Prognosis
Review
Studies
Survival
Survival Analysis
Tumors
Urinary Bladder Neoplasms - blood
Urinary Bladder Neoplasms - pathology
Urinary Bladder Neoplasms - surgery
Urology
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Zusammenfassung:Introduction. A growing number of studies have explored the association between the pretreatment lymphocyte-to-monocyte ratio (LMR) and survival outcomes in various cancers. However, its prognostic significance on bladder cancer remains inconsistent. The aim of this meta-analysis was to evaluate the prognostic value of pretreatment LMR in bladder cancer. Methods. The MEDLINE, EMBASE, Cochrane Library, and CNKI databases were comprehensively searched for relevant studies. A meta-analysis of overall survival (OS), recurrence-free survival (RFS), or cancer-specific survival (CSS) clinicopathological features was conducted. Results. Nine studies containing 5,638 cancer patients were analyzed in this meta-analysis. Patients with high LMR tended to have favourable OS (HR: 0.63, 95% CI: 0.50-0.80, P
ISSN:0278-0240
1875-8630
DOI:10.1155/2019/7593560