Lower DHEA-S levels predict disease and worse outcomes in post-menopausal women with idiopathic, connective tissue disease- and congenital heart disease-associated pulmonary arterial hypertension

Lower DHEA-S levels predict disease and worse outcomes in post-menopausal women with idiopathic, connective tissue disease- and congenital heart disease-associated pulmonary arterial hypertension

High oestradiol (E2) and low dehydroepiandrosterone-sulfate (DHEA-S) levels are risk factors for pulmonary arterial hypertension (PAH) in men, but whether sex hormones are related to PAH in women is unknown.Post-menopausal women aged ≥55 years with PAH were matched by age and body mass index to wome...

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Veröffentlicht in:The European respiratory journal 2018-06, Vol.51 (6), p.1800467-1800467
Hauptverfasser: Baird, Grayson L, Archer-Chicko, Christine, Barr, R Graham, Bluemke, David A, Foderaro, Andrew E, Fritz, Jason S, Hill, Nicholas S, Kawut, Steven M, Klinger, James R, Lima, Joao A C, Mullin, Christopher J, Ouyang, Pamela, Palevsky, Harold I, Palmisicano, Amy J, Pinder, Diane, Preston, Ioana R, Roberts, Kari E, Smith, K Akaya, Walsh, Thomas, Whittenhall, Mary, Ventetuolo, Corey E
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Body Mass Index
Cardiovascular diseases
Case-Control Studies
Connective Tissue Diseases - complications
Coronary artery disease
Dehydroepiandrosterone
Dehydroepiandrosterone Sulfate - blood
Estradiol - blood
Female
Health risk assessment
Heart Defects, Congenital - complications
Heart diseases
Hemodynamics
Hormone replacement therapy
Humans
Hypertension
Hypertension, Pulmonary - blood
Hypertension, Pulmonary - complications
Lung diseases
Male
Middle Aged
Postmenopause - blood
Proportional Hazards Models
Pulmonary hypertension
Risk Factors
Sex hormones
Sulfate
Ventricle
Walk Test
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Zusammenfassung:High oestradiol (E2) and low dehydroepiandrosterone-sulfate (DHEA-S) levels are risk factors for pulmonary arterial hypertension (PAH) in men, but whether sex hormones are related to PAH in women is unknown.Post-menopausal women aged ≥55 years with PAH were matched by age and body mass index to women without cardiovascular disease. Plasma sex hormone levels were measured by immunoassay.Lower levels of DHEA-S (p
ISSN:0903-1936
1399-3003
DOI:10.1183/13993003.00467-2018