Aberrant DNA Methylation of Two Tumor Suppressor Genes, p14ARF and p15INK4b , after Chronic Occupational Exposure to Low Level of Benzene

Aberrant DNA Methylation of Two Tumor Suppressor Genes, p14ARF and p15INK4b , after Chronic Occupational Exposure to Low Level of Benzene

BACKGROUNDExposure to benzene would be associated with many diseases including leukemia. Epigenetic alterations seem to be among the main mechanisms involved.OBJECTIVETo determine if chronic occupational exposure to low level of benzene would be associated with DNA methylation.METHODSGlobal DNA meth...

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Veröffentlicht in:international journal of occupational and environmental medicine 2018-07, Vol.9 (3), p.145-151
Hauptverfasser: Jamebozorgi, Iraj, Majidizadeh, Tayebeh, Pouryaghoub, Gholamreza, Mahjoubi, Frouzandeh
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Sprache:eng
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Zusammenfassung:BACKGROUNDExposure to benzene would be associated with many diseases including leukemia. Epigenetic alterations seem to be among the main mechanisms involved.OBJECTIVETo determine if chronic occupational exposure to low level of benzene would be associated with DNA methylation.METHODSGlobal DNA methylation and promoter-specific methylation of the two tumor suppressor genes, p14ARF and p15INK4b, were assessed employing methylation-specific PCR using the DNA extracted from 40 petrochemical workers exposed to ambient benzene levels of
ISSN:2008-6520
2008-6814
DOI:10.15171/ijoem.2018.1317