Detection of T lymphocyte subsets and related functional molecules in follicular fluid of patients with polycystic ovary syndrome

Immune responses play an important role in the pathogenesis of polycystic ovary syndrome (PCOS). However, the characteristics of T lymphocyte subsets in PCOS remain insufficiently understood. In this study, lymphocytes of follicular fluid (FF) were obtained from oocyte retrieval before in-vitro fert...

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Veröffentlicht in:	Scientific reports 2019-04, Vol.9 (1), p.6040-6040, Article 6040
Hauptverfasser:	Li, Zitao, Peng, Anping, Feng, Yuanfa, Zhang, Xiaona, Liu, Fenghua, Chen, Chuangqi, Ye, Xin, Qu, Jiale, Jin, Chenxi, Wang, Mei, Qiu, Huaina, Qi, Yanwei, Huang, Jun, Yang, Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 13/31 17β-Estradiol 631/250/2152/1566 692/699/2732/1577 Adult Antigens, CD - analysis Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - analysis Antigens, Differentiation, T-Lymphocyte - immunology Apoptosis CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD69 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Cytokines - analysis Cytokines - immunology Female Fertilization in Vitro Flow cytometry Follicular fluid Follicular Fluid - immunology Humanities and Social Sciences Humans In vitro fertilization Infertility, Female - complications Infertility, Female - immunology Interleukin 10 Interleukin-2 Receptor alpha Subunit - analysis Interleukin-2 Receptor alpha Subunit - immunology Lectins, C-Type - analysis Lectins, C-Type - immunology Lymphocytes Lymphocytes T multidisciplinary Pathogenesis PD-1 protein Polycystic ovary syndrome Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - immunology Science Science (multidisciplinary) T-Lymphocyte Subsets - immunology Young Adult γ-Interferon
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Zusammenfassung:	Immune responses play an important role in the pathogenesis of polycystic ovary syndrome (PCOS). However, the characteristics of T lymphocyte subsets in PCOS remain insufficiently understood. In this study, lymphocytes of follicular fluid (FF) were obtained from oocyte retrieval before in-vitro fertilization (IVF) in infertile women with or without PCOS. The levels of cluster of differentiation 25 (CD25), CD69, programmed death 1 (PD-1), interferon-γ (IFN-γ), interleukin 17A (IL-17A) and IL-10 in T lymphocytes were determined by flow cytometry. Our results showed that the percentage of FF CD8 + T cells was significantly decreased in infertile patients with PCOS ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-42631-x