Tetrasomy 8 Associated with a Poor Prognosis in Acute Monoblastic Leukemia: A Case Report

Tetrasomy 8 Associated with a Poor Prognosis in Acute Monoblastic Leukemia: A Case Report

We report a case of a 47-year-old male from West Africa who presented with sepsis and was found to have acute monoblastic leukemia associated with tetrasomy 8 detected on bone marrow samples. This was the only chromosomal abnormality found. Tetrasomy 8 is a rare genetic finding that has been reporte...

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Veröffentlicht in:Curēus (Palo Alto, CA) CA), 2019-02, Vol.11 (2), p.e4068
Hauptverfasser: Farag, Fady, Morcus, Rewais, Ramachandran, Preethi, Josan, Karan, Wang, Jen Chin
Format: Artikel
Sprache:eng
Schlagworte:
Abdomen
Bone marrow
Case reports
Chromosomes
Cloning
Genes
Genetics
Hybridization
Leukemia
Medical prognosis
Mutation
Oncology
Pneumonia
Sepsis
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Zusammenfassung:We report a case of a 47-year-old male from West Africa who presented with sepsis and was found to have acute monoblastic leukemia associated with tetrasomy 8 detected on bone marrow samples. This was the only chromosomal abnormality found. Tetrasomy 8 is a rare genetic finding that has been reported in acute myeloid leukemia (AML), predominantly the monocytic lineage. It carries a poor prognosis with a high mortality rate.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.4068