Use of Adjuvant Pharmacotherapy in Type 1 Diabetes: International Comparison of 49,996 Individuals in the Prospective Diabetes Follow-up and T1D Exchange Registries

Lyons et al examine the use of adjunctive pharmacotherapy in type 1 diabetes (T1D). The use of any adjuvant medication was 5.4% in T1D Exchange (T1DX) and 1.6% in DPV (P < 0.001). Metformin was the most commonly reported medication in both registries, with 3.5% in the T1DX and 1.3% in the DPV (P < 0.001). For the T1DX, GLP-1 agonists were next (0.91%), followed by SGLT2 inhibitors (0.63%) and DPP-4 inhibitors (0.04%). In DPV, DPP-4 inhibitor use frequency was 0.13%, followed by that of SGLT2 inhibitors (0.13%) and GLP-1 agonists (0.07%). "Other" medications, which included pramlintide (T1DX only), sulfonylureas, and incretin therapy of unknown type, were the third most common agents used in T1DX and second in DPV (0.86% and 0.21%, respectively). The frequency of adjuvant medication increased with age for combined registry data. However, when separated by registry, adjuvant use was highest in those aged 26 to