The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery

Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We d...

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Veröffentlicht in:Natural product reports 2019-05, Vol.36 (5), p.698-713
Hauptverfasser: Jamieson, Cooper S, Ohashi, Masao, Liu, Fang, Tang, Yi, Houk, K. N
Format: Artikel
Sprache:eng
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Zusammenfassung:Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We define the scope of pericyclic reactions, give a historical account of their discoveries as biosynthetic reactions, and provide evidence that there are many enzymes in nature that catalyze pericyclic reactions. These enzymes, the "pericyclases," are the subject of this review. The pericyclases are Nature's route to spirotetronates, statins, myceliothermophins, leporins and more.
ISSN:0265-0568
1460-4752
DOI:10.1039/c8np00075a