Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals

Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci ( P

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Veröffentlicht in:	Communications biology 2019-04, Vol.2 (1), p.115, Article 115
Hauptverfasser:	Nakatochi, Masahiro, Kanai, Masahiro, Nakayama, Akiyoshi, Hishida, Asahi, Kawamura, Yusuke, Ichihara, Sahoko, Akiyama, Masato, Ikezaki, Hiroaki, Furusyo, Norihiro, Shimizu, Seiko, Yamamoto, Ken, Hirata, Makoto, Okada, Rieko, Kawai, Sayo, Kawaguchi, Makoto, Nishida, Yuichiro, Shimanoe, Chisato, Ibusuki, Rie, Takezaki, Toshiro, Nakajima, Mayuko, Takao, Mikiya, Ozaki, Etsuko, Matsui, Daisuke, Nishiyama, Takeshi, Suzuki, Sadao, Takashima, Naoyuki, Kita, Yoshikuni, Endoh, Kaori, Kuriki, Kiyonori, Uemura, Hirokazu, Arisawa, Kokichi, Oze, Isao, Matsuo, Keitaro, Nakamura, Yohko, Mikami, Haruo, Tamura, Takashi, Nakashima, Hiroshi, Nakamura, Takahiro, Kato, Norihiro, Matsuda, Koichi, Murakami, Yoshinori, Matsubara, Tatsuaki, Naito, Mariko, Kubo, Michiaki, Kamatani, Yoichiro, Shinomiya, Nariyoshi, Yokota, Mitsuhiro, Wakai, Kenji, Okada, Yukinori, Matsuo, Hirotaka
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/43 631/208/205/2138 692/699/1670/3/2765/1528 Alleles Arthritis Biology Biomedical and Life Sciences Computational Biology Gene loci Gene regulation Genetic Predisposition to Disease Genome-Wide Association Study Genomes Genotype Gout Gout - blood Gout - etiology Gout - metabolism Hepatocyte nuclear factor 4 Humans Hyperuricemia Japan Life Sciences Meta-analysis Molecular Sequence Annotation Oxidative metabolism Oxidative stress Polymorphism, Single Nucleotide Quantitative Trait Loci Quantitative Trait, Heritable Rheumatism Uric acid Uric Acid - blood
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Beschreibung
Zusammenfassung:	Gout is a common arthritis caused by elevated serum uric acid (SUA) levels. Here we investigated loci influencing SUA in a genome-wide meta-analysis with 121,745 Japanese subjects. We identified 8948 variants at 36 genomic loci ( P
ISSN:	2399-3642 2399-3642
DOI:	10.1038/s42003-019-0339-0