Emerging roles for extracellular vesicles in parasitic infections
Highlights • Parasites secrete extracellular vesicles (EVs) that mediate cellular communication. • EVs can transfer virulence factors, drug-resistance markers and modify host response. • MicroRNAs contained in EVs have been shown to down-regulate host cell proteins. • EVs can support parasite growth...
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| Veröffentlicht in: | Current opinion in microbiology 2016-08, Vol.32, p.66-70 |
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| container_title | Current opinion in microbiology |
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| creator | Marti, Matthias Johnson, Patricia J |
| description | Highlights • Parasites secrete extracellular vesicles (EVs) that mediate cellular communication. • EVs can transfer virulence factors, drug-resistance markers and modify host response. • MicroRNAs contained in EVs have been shown to down-regulate host cell proteins. • EVs can support parasite growth as well as host cell proliferation. • Most described parasite EVs either suppress or stimulate the host immune response. |
| doi_str_mv | 10.1016/j.mib.2016.04.008 |
| format | Article |
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Johnson, Patricia J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-91a6bc0d6ca60262313a13ca833a4615b17a013ae5193fea7606995f7ca7701a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Cell Adhesion - physiology</topic><topic>Cell Communication - physiology</topic><topic>Cell Proliferation</topic><topic>Cryptosporidium - metabolism</topic><topic>Cryptosporidium - pathogenicity</topic><topic>drug resistance</topic><topic>Erythrocytes - parasitology</topic><topic>Extracellular Vesicles - physiology</topic><topic>gene expression</topic><topic>Host-Parasite Interactions - physiology</topic><topic>immune response</topic><topic>Leishmania - metabolism</topic><topic>Leishmania - pathogenicity</topic><topic>lipids</topic><topic>mammals</topic><topic>MicroRNAs - genetics</topic><topic>neoplasms</topic><topic>parasites</topic><topic>parasitoses</topic><topic>Pathology</topic><topic>Plasmodium - metabolism</topic><topic>Plasmodium - pathogenicity</topic><topic>proteins</topic><topic>Signal Transduction</topic><topic>Trichomonas vaginalis - immunology</topic><topic>Trichomonas vaginalis - metabolism</topic><topic>Trichomonas vaginalis - pathogenicity</topic><topic>Trypanosoma - metabolism</topic><topic>Trypanosoma - pathogenicity</topic><topic>virulence</topic><topic>Virulence Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marti, Matthias</creatorcontrib><creatorcontrib>Johnson, Patricia J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current opinion in microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marti, Matthias</au><au>Johnson, Patricia J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging roles for extracellular vesicles in parasitic infections</atitle><jtitle>Current opinion in microbiology</jtitle><addtitle>Curr Opin Microbiol</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>32</volume><spage>66</spage><epage>70</epage><pages>66-70</pages><issn>1369-5274</issn><eissn>1879-0364</eissn><abstract>Highlights • Parasites secrete extracellular vesicles (EVs) that mediate cellular communication. • EVs can transfer virulence factors, drug-resistance markers and modify host response. • MicroRNAs contained in EVs have been shown to down-regulate host cell proteins. • EVs can support parasite growth as well as host cell proliferation. • Most described parasite EVs either suppress or stimulate the host immune response.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27208506</pmid><doi>10.1016/j.mib.2016.04.008</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1369-5274 |
| ispartof | Current opinion in microbiology, 2016-08, Vol.32, p.66-70 |
| issn | 1369-5274 1879-0364 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6445373 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Cell Adhesion - physiology Cell Communication - physiology Cell Proliferation Cryptosporidium - metabolism Cryptosporidium - pathogenicity drug resistance Erythrocytes - parasitology Extracellular Vesicles - physiology gene expression Host-Parasite Interactions - physiology immune response Leishmania - metabolism Leishmania - pathogenicity lipids mammals MicroRNAs - genetics neoplasms parasites parasitoses Pathology Plasmodium - metabolism Plasmodium - pathogenicity proteins Signal Transduction Trichomonas vaginalis - immunology Trichomonas vaginalis - metabolism Trichomonas vaginalis - pathogenicity Trypanosoma - metabolism Trypanosoma - pathogenicity virulence Virulence Factors |
| title | Emerging roles for extracellular vesicles in parasitic infections |
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