Emerging roles for extracellular vesicles in parasitic infections

Highlights • Parasites secrete extracellular vesicles (EVs) that mediate cellular communication. • EVs can transfer virulence factors, drug-resistance markers and modify host response. • MicroRNAs contained in EVs have been shown to down-regulate host cell proteins. • EVs can support parasite growth...

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Veröffentlicht in:	Current opinion in microbiology 2016-08, Vol.32, p.66-70
Hauptverfasser:	Marti, Matthias, Johnson, Patricia J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion - physiology Cell Communication - physiology Cell Proliferation Cryptosporidium - metabolism Cryptosporidium - pathogenicity drug resistance Erythrocytes - parasitology Extracellular Vesicles - physiology gene expression Host-Parasite Interactions - physiology immune response Leishmania - metabolism Leishmania - pathogenicity lipids mammals MicroRNAs - genetics neoplasms parasites parasitoses Pathology Plasmodium - metabolism Plasmodium - pathogenicity proteins Signal Transduction Trichomonas vaginalis - immunology Trichomonas vaginalis - metabolism Trichomonas vaginalis - pathogenicity Trypanosoma - metabolism Trypanosoma - pathogenicity virulence Virulence Factors
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Beschreibung
Zusammenfassung:	Highlights • Parasites secrete extracellular vesicles (EVs) that mediate cellular communication. • EVs can transfer virulence factors, drug-resistance markers and modify host response. • MicroRNAs contained in EVs have been shown to down-regulate host cell proteins. • EVs can support parasite growth as well as host cell proliferation. • Most described parasite EVs either suppress or stimulate the host immune response.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2016.04.008