Serine-threonine kinases in TCR signaling

TCR engagement triggers activation of downstream kinases. Navarro and Cantrell discuss how the network of serine/threonine kinases instruct T cell metabolism to participate in immune responses. T lymphocyte proliferation and differentiation are controlled by signaling pathways initiated by the T cell antigen receptor. Here we explore how key serine-threonine kinases and their substrates mediate T cell signaling and coordinate T cell metabolism to meet the metabolic demands of participating in an immune response.