External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data From 140 US Hospitals

External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data From 140 US Hospitals

Abstract Difficult-to-treat resistance (DTR; ie, co-resistance to all first-line antibiotics) in gram-negative bloodstream infection (GNBSI) is associated with decreased survival in administrative data models. We externally validated DTR prevalence and associated mortality risk in GNBSI using detail...

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Veröffentlicht in:Open Forum Infectious Diseases 2019-04, Vol.6 (4), p.ofz110
Hauptverfasser: Kadri, Sameer S, Lai, Yi Ling (Elaine), Ricotta, Emily E, Strich, Jeffrey R, Babiker, Ahmed, Rhee, Chanu, Klompas, Michael, Dekker, John P, Powers, John H, Danner, Robert L, Adjemian, Jennifer
Format: Artikel
Sprache:eng
Schlagworte:
Brief Reports
Drug resistance in microorganisms
Editor's Choice
Electronic records
Health aspects
Infection
Maryland
Medical records
Mortality
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Zusammenfassung:Abstract Difficult-to-treat resistance (DTR; ie, co-resistance to all first-line antibiotics) in gram-negative bloodstream infection (GNBSI) is associated with decreased survival in administrative data models. We externally validated DTR prevalence and associated mortality risk in GNBSI using detailed clinical data from electronic health records to adjust for baseline differences in acute illness severity.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofz110