Human Immunodeficiency Virus (HIV) 2 Superinfection in a Patient Receiving Antiretroviral Therapy With Longstanding HIV-1 Viral Load Suppression
Abstract Dual human immunodeficiency virus (HIV) 1 and HIV-2 superinfections are rare but challenging. A HIV-1–infected patient receiving effective antiretroviral therapy was investigated for a severe CD4+ cell count decline. HIV-2 superinfection was diagnosed and genotypic test revealed mutations c...
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| Veröffentlicht in: | Open Forum Infectious Diseases 2019-04, Vol.6 (4), p.ofz063-ofz063 |
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| container_end_page | ofz063 |
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| container_issue | 4 |
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| container_title | Open Forum Infectious Diseases |
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| creator | Ceia, F Silva-Pinto, A Carvalho, A C Piñeiro, C Soares, J Serrão, R Sarmento, A |
| description | Abstract
Dual human immunodeficiency virus (HIV) 1 and HIV-2 superinfections are rare but challenging. A HIV-1–infected patient receiving effective antiretroviral therapy was investigated for a severe CD4+ cell count decline. HIV-2 superinfection was diagnosed and genotypic test revealed mutations conferring resistance to most drug class, limiting options for treatment. |
| doi_str_mv | 10.1093/ofid/ofz063 |
| format | Article |
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Dual human immunodeficiency virus (HIV) 1 and HIV-2 superinfections are rare but challenging. A HIV-1–infected patient receiving effective antiretroviral therapy was investigated for a severe CD4+ cell count decline. HIV-2 superinfection was diagnosed and genotypic test revealed mutations conferring resistance to most drug class, limiting options for treatment.</description><identifier>ISSN: 2328-8957</identifier><identifier>EISSN: 2328-8957</identifier><identifier>DOI: 10.1093/ofid/ofz063</identifier><identifier>PMID: 30949532</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Anti-HIV agents ; Antiviral agents ; Atazanavir ; Brief Reports ; Care and treatment ; Darunavir ; Health aspects ; Highly active antiretroviral therapy ; HIV (Viruses) ; HIV infection ; Infection ; Medical research ; Medicine, Experimental ; Reverse transcriptase inhibitors ; Type 2 diabetes</subject><ispartof>Open Forum Infectious Diseases, 2019-04, Vol.6 (4), p.ofz063-ofz063</ispartof><rights>The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2019</rights><rights>COPYRIGHT 2019 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-dc826adbe0245da964fa14356376127c40797dbafe1697e88a10d4b145a5c01e3</citedby><cites>FETCH-LOGICAL-c436t-dc826adbe0245da964fa14356376127c40797dbafe1697e88a10d4b145a5c01e3</cites><orcidid>0000-0002-2077-3356</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441564/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441564/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1598,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30949532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ceia, F</creatorcontrib><creatorcontrib>Silva-Pinto, A</creatorcontrib><creatorcontrib>Carvalho, A C</creatorcontrib><creatorcontrib>Piñeiro, C</creatorcontrib><creatorcontrib>Soares, J</creatorcontrib><creatorcontrib>Serrão, R</creatorcontrib><creatorcontrib>Sarmento, A</creatorcontrib><title>Human Immunodeficiency Virus (HIV) 2 Superinfection in a Patient Receiving Antiretroviral Therapy With Longstanding HIV-1 Viral Load Suppression</title><title>Open Forum Infectious Diseases</title><addtitle>Open Forum Infect Dis</addtitle><description>Abstract
Dual human immunodeficiency virus (HIV) 1 and HIV-2 superinfections are rare but challenging. A HIV-1–infected patient receiving effective antiretroviral therapy was investigated for a severe CD4+ cell count decline. HIV-2 superinfection was diagnosed and genotypic test revealed mutations conferring resistance to most drug class, limiting options for treatment.</description><subject>Anti-HIV agents</subject><subject>Antiviral agents</subject><subject>Atazanavir</subject><subject>Brief Reports</subject><subject>Care and treatment</subject><subject>Darunavir</subject><subject>Health aspects</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV (Viruses)</subject><subject>HIV infection</subject><subject>Infection</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Reverse transcriptase inhibitors</subject><subject>Type 2 diabetes</subject><issn>2328-8957</issn><issn>2328-8957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kUFrHCEUgIfS0IQkp96Lp5ISJlXHccZLYQltd2EhpU3To7j6ZtcyoxOdWdj-ivzkOkwS0ksRVPR7n-_5suwtwVcEi-Kjb6xJ0x_Mi1fZCS1ondeirF6_2B9n5zH-xhgTgktciTfZcYEFE2VBT7KH5dgph1ZdNzpvoLHagtMHdGfDGNHFcnX3AVH0Y-whWNeAHqx3yDqk0Dc1JHRA30GD3Vu3RQs32ABD8HsbVItudxBUf0C_7LBDa--2cVDOTGCy5mR6IlFrr8zk7wPEmORn2VGj2gjnj-tp9vPL59vrZb6--bq6XqxzzQo-5EbXlCuzAUxZaZTgrFGEFSUvKk5opVkqtDIb1QDhooK6VgQbtiGsVKXGBIrT7NPs7cdNB0anUlI6sg-2U-EgvbLy3xtnd3Lr95IzRkrOkuDiURD8_QhxkJ2NGtpWOfBjlJRixgVmhCb0aka3qgWZ_tEno07DQGe1d-nb0_mC14JVgpZ1CricA3TwMQZonvMiWE59l1Pf5dz3RL97Wcoz-9TlBLyfAT_2_zX9Bd7VuRw</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Ceia, F</creator><creator>Silva-Pinto, A</creator><creator>Carvalho, A C</creator><creator>Piñeiro, C</creator><creator>Soares, J</creator><creator>Serrão, R</creator><creator>Sarmento, A</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2077-3356</orcidid></search><sort><creationdate>20190401</creationdate><title>Human Immunodeficiency Virus (HIV) 2 Superinfection in a Patient Receiving Antiretroviral Therapy With Longstanding HIV-1 Viral Load Suppression</title><author>Ceia, F ; Silva-Pinto, A ; Carvalho, A C ; Piñeiro, C ; Soares, J ; Serrão, R ; Sarmento, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-dc826adbe0245da964fa14356376127c40797dbafe1697e88a10d4b145a5c01e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anti-HIV agents</topic><topic>Antiviral agents</topic><topic>Atazanavir</topic><topic>Brief Reports</topic><topic>Care and treatment</topic><topic>Darunavir</topic><topic>Health aspects</topic><topic>Highly active antiretroviral therapy</topic><topic>HIV (Viruses)</topic><topic>HIV infection</topic><topic>Infection</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Reverse transcriptase inhibitors</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ceia, F</creatorcontrib><creatorcontrib>Silva-Pinto, A</creatorcontrib><creatorcontrib>Carvalho, A C</creatorcontrib><creatorcontrib>Piñeiro, C</creatorcontrib><creatorcontrib>Soares, J</creatorcontrib><creatorcontrib>Serrão, R</creatorcontrib><creatorcontrib>Sarmento, A</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Open Forum Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ceia, F</au><au>Silva-Pinto, A</au><au>Carvalho, A C</au><au>Piñeiro, C</au><au>Soares, J</au><au>Serrão, R</au><au>Sarmento, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Immunodeficiency Virus (HIV) 2 Superinfection in a Patient Receiving Antiretroviral Therapy With Longstanding HIV-1 Viral Load Suppression</atitle><jtitle>Open Forum Infectious Diseases</jtitle><addtitle>Open Forum Infect Dis</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>6</volume><issue>4</issue><spage>ofz063</spage><epage>ofz063</epage><pages>ofz063-ofz063</pages><issn>2328-8957</issn><eissn>2328-8957</eissn><abstract>Abstract
Dual human immunodeficiency virus (HIV) 1 and HIV-2 superinfections are rare but challenging. A HIV-1–infected patient receiving effective antiretroviral therapy was investigated for a severe CD4+ cell count decline. HIV-2 superinfection was diagnosed and genotypic test revealed mutations conferring resistance to most drug class, limiting options for treatment.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>30949532</pmid><doi>10.1093/ofid/ofz063</doi><orcidid>https://orcid.org/0000-0002-2077-3356</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2328-8957 |
| ispartof | Open Forum Infectious Diseases, 2019-04, Vol.6 (4), p.ofz063-ofz063 |
| issn | 2328-8957 2328-8957 |
| language | eng |
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| source | Oxford Journals Open Access Collection; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Anti-HIV agents Antiviral agents Atazanavir Brief Reports Care and treatment Darunavir Health aspects Highly active antiretroviral therapy HIV (Viruses) HIV infection Infection Medical research Medicine, Experimental Reverse transcriptase inhibitors Type 2 diabetes |
| title | Human Immunodeficiency Virus (HIV) 2 Superinfection in a Patient Receiving Antiretroviral Therapy With Longstanding HIV-1 Viral Load Suppression |
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