Human Immunodeficiency Virus (HIV) 2 Superinfection in a Patient Receiving Antiretroviral Therapy With Longstanding HIV-1 Viral Load Suppression

Human Immunodeficiency Virus (HIV) 2 Superinfection in a Patient Receiving Antiretroviral Therapy With Longstanding HIV-1 Viral Load Suppression

Abstract Dual human immunodeficiency virus (HIV) 1 and HIV-2 superinfections are rare but challenging. A HIV-1–infected patient receiving effective antiretroviral therapy was investigated for a severe CD4+ cell count decline. HIV-2 superinfection was diagnosed and genotypic test revealed mutations c...

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Veröffentlicht in:Open Forum Infectious Diseases 2019-04, Vol.6 (4), p.ofz063-ofz063
Hauptverfasser: Ceia, F, Silva-Pinto, A, Carvalho, A C, Piñeiro, C, Soares, J, Serrão, R, Sarmento, A
Format: Artikel
Sprache:eng
Schlagworte:
Anti-HIV agents
Antiviral agents
Atazanavir
Brief Reports
Care and treatment
Darunavir
Health aspects
Highly active antiretroviral therapy
HIV (Viruses)
HIV infection
Infection
Medical research
Medicine, Experimental
Reverse transcriptase inhibitors
Type 2 diabetes
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Zusammenfassung:Abstract Dual human immunodeficiency virus (HIV) 1 and HIV-2 superinfections are rare but challenging. A HIV-1–infected patient receiving effective antiretroviral therapy was investigated for a severe CD4+ cell count decline. HIV-2 superinfection was diagnosed and genotypic test revealed mutations conferring resistance to most drug class, limiting options for treatment.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofz063