Do Statins Have a Positive Impact on Patients with Coronary Microvascular Dysfunction on Long-Term Clinical Outcome? A Large Retrospective Cohort Study

Objectives. To investigate the influence of statins on major adverse cardiovascular events (MACE) in patients with coronary microvascular dysfunction (CMVD). Participants. 23,494 patients who received coronary angiography (CAG) were included. Thrombolysis in Myocardial Infarction, Myocardial Perfusi...

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Veröffentlicht in:	BioMed research international 2019-01, Vol.2019 (2019), p.1-8
Hauptverfasser:	Zhang, Pei-dong, Huang, Jie-wu, Guo, Yang, Luo, Wen-hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Angiography Aspirin Aspirin - administration & dosage Blood Cardiac patients Cardiology Cardiovascular agents Cardiovascular disease Clinical outcomes Cohort analysis Coronary Angiography Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - drug therapy Coronary Artery Disease - epidemiology Coronary Artery Disease - pathology Coronary vessels Creatinine Diabetes Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - epidemiology Diabetes Mellitus - pathology Drug-Related Side Effects and Adverse Reactions - pathology Evaluation Female Heart attack Heart attacks Heart beat Heart rate Hospitals Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hypertension Hypertension - diagnostic imaging Hypertension - drug therapy Hypertension - epidemiology Hypertension - pathology Male Medical imaging Microvasculature Middle Aged Multivariate analysis Myocardial infarction Myocardial Infarction - drug therapy Myocardial Infarction - epidemiology Myocardial Infarction - pathology Myocardial Perfusion Imaging Patient outcomes Patients Perfusion Retrospective Studies Smoking Smoking - adverse effects Statins Subgroups Thrombolysis Treatment Outcome Trinucleotide repeats
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Beschreibung
Zusammenfassung:	Objectives. To investigate the influence of statins on major adverse cardiovascular events (MACE) in patients with coronary microvascular dysfunction (CMVD). Participants. 23,494 patients who received coronary angiography (CAG) were included. Thrombolysis in Myocardial Infarction, Myocardial Perfusion Grading (TMPG), a useful angiographic method, was used to evaluate CMVD. Results. Using multivariate analysis, NYHA III/IV (HR, 1.44; 95% CI, 1.03-2.01; P=0.031), PCI history (HR, 3.69; 95% CI, 2.57-5.31; P
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2019/4069097