Effect of chronic opioid therapy on pain and survival in a humanized mouse model of sickle cell disease

The use of opioid analgesics in patients with sickle cell disease who develop painful crises is an unfortunate reality. Gupta and colleagues explore the impact of opioids on the survival of humanized mice with this disorder, resulting in important differences as compared to normal mice. Their findin...

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Veröffentlicht in:	Blood advances 2019-03, Vol.3 (6), p.869-873
Hauptverfasser:	Tran, Huy, Sagi, Varun, Leonce Song-Naba, Waogwende, Wang, Ying, Mittal, Aditya, Lamarre, Yann, Zhang, Lei, Gupta, Kalpna
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - adverse effects Analgesics, Opioid - therapeutic use Anemia, Sickle Cell - drug therapy Anemia, Sickle Cell - mortality Anemia, Sickle Cell - pathology Animals Female Humans Hyperalgesia - chemically induced Male Mice Morphine - adverse effects Morphine - therapeutic use Pain - drug therapy Pain - etiology Stimulus Report Survival Rate
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Beschreibung
Zusammenfassung:	The use of opioid analgesics in patients with sickle cell disease who develop painful crises is an unfortunate reality. Gupta and colleagues explore the impact of opioids on the survival of humanized mice with this disorder, resulting in important differences as compared to normal mice. Their findings could have significant clinical consequences.
ISSN:	2473-9529 2473-9537
DOI:	10.1182/bloodadvances.2018024299