Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis

Intratumor heterogeneity associates with cancer progression and may account for a substantial portion of therapeutic resistance. Although extensive studies have focused on the origin of the heterogeneity, biological interactions between heterogeneous malignant cells within a tumor are largely unexpl...

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Veröffentlicht in:	Journal of cell science 2019-03, Vol.132 (5)
Hauptverfasser:	Liu, Zhijun, Yee, Patricia P, Wei, Yiju, Liu, Zhenqiu, Kawasawa, Yuka Imamura, Li, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis - genetics Brain Neoplasms - genetics Brain Neoplasms - pathology Carcinogenesis - genetics Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Proliferation - genetics Female Gene Expression Regulation, Neoplastic Glioma - genetics Glioma - pathology Heterografts Humans Mice Mice, Nude Neoplasm Transplantation Neoplasms, Experimental Sequence Analysis, RNA Spheroids, Cellular - pathology Tumor Cells, Cultured YAP-Signaling Proteins
Online-Zugang:	Volltext
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