Associations of Common Variants in HFE and TMPRSS6 Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease

Background. Influence of TMPRSS6 A736V and HFE (C282Y and H63D) polymorphisms on serum hepcidin-25 levels and iron status parameters in end-stage renal disease (ESRD) patients stratified according to gender has not been previously investigated. In addition, we aimed to evaluate the diagnostic accura...

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Veröffentlicht in:	Disease markers 2019-01, Vol.2019 (2019), p.1-10
Hauptverfasser:	Simic-Ogrizovic, Sanja, Novaković, Ivana, Milinković, Neda, Savković, Miljan, Topić, Aleksandra, Dopsaj, Violeta, Ćujić, Danica
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Anemia Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - genetics Binding sites Blood & organ donations Care and treatment Chronic illnesses Chronic kidney failure Diabetes Diagnosis Diagnostic systems End-stage renal disease Epidemiology Erythropoietin, Recombinant Female Ferritin Ferritins - blood Genes Genetic analysis Genetic aspects Haplotypes Hemochromatosis Protein - genetics Hemoglobin Hepcidin Hepcidins - blood Humans Inflammation Iron Iron - blood Iron deficiency Iron deficiency anemia Kidney diseases Kidney Failure, Chronic - blood Kidney Failure, Chronic - genetics Kidney Failure, Chronic - pathology Male Membrane Proteins - genetics Metabolism Middle Aged Mutation Nephrology Nutrient deficiency Parameters Patients Polymorphism Polymorphism, Single Nucleotide Population Proteins Serine Endopeptidases - genetics Transferrin Transferrin - analysis Transferrins Womens health
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Zusammenfassung:	Background. Influence of TMPRSS6 A736V and HFE (C282Y and H63D) polymorphisms on serum hepcidin-25 levels and iron status parameters in end-stage renal disease (ESRD) patients stratified according to gender has not been previously investigated. In addition, we aimed to evaluate the diagnostic accuracy of the parameters to separate iron-deficiency anemia (IDA) from anemia of chronic disease. Materials and Methods. Iron status parameters and genetic analysis were performed in 126 ESRD patients and in 31 IDA patients as the control group. Results. ESRD patients had significantly higher ferritin and hepcidin-25 (
ISSN:	0278-0240 1875-8630 1875-8630
DOI:	10.1155/2019/4864370