What has de novo protein design taught us about protein folding and biophysics?
Recent progress in de novo protein design has led to an explosion of new protein structures, functions and assemblies. In this essay, I consider how the successes and failures in this new area inform our understanding of the proteins in nature and, more generally, the predictive computational modeli...
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| Veröffentlicht in: | Protein science 2019-04, Vol.28 (4), p.678-683 |
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| container_title | Protein science |
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| creator | Baker, David |
| description | Recent progress in de novo protein design has led to an explosion of new protein structures, functions and assemblies. In this essay, I consider how the successes and failures in this new area inform our understanding of the proteins in nature and, more generally, the predictive computational modeling of biological systems. |
| doi_str_mv | 10.1002/pro.3588 |
| format | Article |
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| ispartof | Protein science, 2019-04, Vol.28 (4), p.678-683 |
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| language | eng |
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| source | MEDLINE; Wiley-Blackwell Full Collection; Wiley-Blackwell Free Backfiles(OpenAccess); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Biological computing Biophysical Phenomena Biophysics computational modeling Computer applications Humans Kinetics Protein Conformation protein design Protein Folding Protein Stability Proteins Proteins - chemistry Review Reviews Thermodynamics |
| title | What has de novo protein design taught us about protein folding and biophysics? |
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