What has de novo protein design taught us about protein folding and biophysics?

Recent progress in de novo protein design has led to an explosion of new protein structures, functions and assemblies. In this essay, I consider how the successes and failures in this new area inform our understanding of the proteins in nature and, more generally, the predictive computational modeli...

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Veröffentlicht in:Protein science 2019-04, Vol.28 (4), p.678-683
1. Verfasser: Baker, David
Format: Artikel
Sprache:eng
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Zusammenfassung:Recent progress in de novo protein design has led to an explosion of new protein structures, functions and assemblies. In this essay, I consider how the successes and failures in this new area inform our understanding of the proteins in nature and, more generally, the predictive computational modeling of biological systems.
ISSN:0961-8368
1469-896X
DOI:10.1002/pro.3588