Potential therapeutic targets for atherosclerosis in sphingolipid metabolism

Sphingolipids, such as sphingomyelins, ceramides, glycosphingolipids, and sphingosine-1-phosphates (S1P) are a large group of structurally and functionally diverse molecules. Some specific species are found associated with atherogenesis and provide novel therapeutic targets. Herein, we briefly revie...

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Veröffentlicht in:	Clinical science (1979) 2019-03, Vol.133 (6), p.763-776
Hauptverfasser:	Yu, Zemou, Peng, Qing, Huang, Yining
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis - drug therapy Atherosclerosis - metabolism Cardiovascular Agents - pharmacology Cardiovascular Agents - therapeutic use Ceramides - metabolism Humans Molecular Targeted Therapy - methods Review Sphingolipids - metabolism Sphingolipids - physiology Sphingomyelin Phosphodiesterase - antagonists & inhibitors Sphingomyelin Phosphodiesterase - physiology Sphingomyelins - metabolism
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Zusammenfassung:	Sphingolipids, such as sphingomyelins, ceramides, glycosphingolipids, and sphingosine-1-phosphates (S1P) are a large group of structurally and functionally diverse molecules. Some specific species are found associated with atherogenesis and provide novel therapeutic targets. Herein, we briefly review how sphingolipids are implicated in the progression of atherosclerosis and related diseases, and then we discuss the potential therapy options by targetting several key enzymes in sphingolipid metabolism.
ISSN:	0143-5221 1470-8736
DOI:	10.1042/cs20180911