Chronic pulmonary aspergillosis commonly complicates treated pulmonary tuberculosis with residual cavitation

Chronic pulmonary aspergillosis (CPA) complicates treated pulmonary tuberculosis (TB), with high 5-year mortality. We measured CPA prevalence in this group.398 Ugandans with treated pulmonary TB underwent clinical assessment, chest radiography and -specific IgG measurement. 285 were resurveyed 2 yea...

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Veröffentlicht in:The European respiratory journal 2019-03, Vol.53 (3), p.1801184
Hauptverfasser: Page, Iain D, Byanyima, Rosemary, Hosmane, Sharath, Onyachi, Nathan, Opira, Cyprian, Richardson, Malcolm, Sawyer, Richard, Sharman, Anna, Denning, David W
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Sprache:eng
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Zusammenfassung:Chronic pulmonary aspergillosis (CPA) complicates treated pulmonary tuberculosis (TB), with high 5-year mortality. We measured CPA prevalence in this group.398 Ugandans with treated pulmonary TB underwent clinical assessment, chest radiography and -specific IgG measurement. 285 were resurveyed 2 years later, including computed tomography of the thorax in 73 with suspected CPA. CPA was diagnosed in patients without active TB who had raised specific IgG, radiological features of CPA and chronic cough or haemoptysis.Author-defined CPA was present in 14 (4.9%, 95% CI 2.8-7.9%) resurvey patients. CPA was significantly more common in those with chest radiography cavitation (26% 0.8%; p
ISSN:0903-1936
1399-3003
DOI:10.1183/13993003.01184-2018